DataVXACS Applied Materials & InterfacesPaper
journal article·2016-03-30Open access

Neoglycoenzyme-Gated Mesoporous Silica Nanoparticles: Toward the Design of Nanodevices for Pulsatile Programmed Sequential Delivery

Paula Díez, Alfredo Sánchez, Cristina de la Torre, María Gamella, Paloma Martínez-Ruíz, Elena Aznar, Ramón Martínez-Máñez, José M. Pingarrón, Reynaldo Villalonga

ACS Applied Materials & Interfaces· Volume 8· Issue 12
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Source abstract

Abstract

We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous silica nanoparticles. The dual-release mechanism was based on the distinct stability of the cyclic boronic acid esters formed with lactose residues and the long naturally occurring glycosylation chains in the modified neoglycoenzyme. Cargo delivery in succession was achieved using glucose and ethyl butyrate as triggers.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Glycosylation and Glycoproteins Research · Nanoparticle-Based Drug Delivery · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain

Instituto de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, 46022 Valencia, Spain

Departamento de Química y CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Universidad Politécnica de Valencia, Camino de Vera s/n, 46022 Valencia, Spain

Department of Organic Chemistry I, Faculty of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain

IMDEA Nanoscience, Cantoblanco Universitary City, 28049 Madrid, Spain

Funding

Generalitat Valenciana · Ministerio de Ciencia e Innovaci?n · Comunidad de Madrid

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