Oxygen-Generating Biomaterials for Translational Bone Regenerative Engineering
Source abstract
Abstract
Successful regeneration of critical-size defects remains one of the significant challenges in regenerative engineering. These large-scale bone defects are difficult to regenerate and are often reconstructed with matrices that do not provide adequate oxygen levels to stem cells involved in the regeneration process. Hypoxia-induced necrosis predominantly occurs in the center of large matrices since the host tissue's local vasculature fails to provide sufficient nutrients and oxygen. Indeed, utilizing oxygen-generating materials can overcome the central hypoxic region, induce tissue in-growth, and increase the quality of life for patients with extensive tissue damage. This article reviews recent advances in oxygen-generating biomaterials for translational bone regenerative engineering. We discussed different oxygen-releasing and delivery methods, fabrication methods for oxygen-releasing matrices, biology, oxygen's role in bone regeneration, and emerging new oxygen delivery methods that could potentially be used for bone regenerative engineering.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Tissue Engineering and Regenerative Medicine · Mesenchymal stem cell research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Connecticut Convergence Institute for Translation in Regenerative Engineering, UConn Health, Farmington, Connecticut 06030, United States
Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, UConn Health, Farmington, Connecticut 06030, United States
Department of Skeletal Biology and Regeneration, UConn Health, Farmington, Connecticut 06030, United States
Department of Orthopedic Surgery, UConn Health, Farmington, Connecticut 06030, United States
Department of Materials Science and Engineering, University of Connecticut, Storrs, Connecticut 06269, United States
Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269, United States
Funding
National Institute of Dental and Craniofacial Research · National Institute of Arthritis and Musculoskeletal and Skin Diseases
References (100+)
Show source-provided references
1. 10.1007/s40883-022-00274-x10.1007/s40883-022-00274-x ↗
2. 10.1007/s40883-021-00229-810.1007/s40883-021-00229-8 ↗
3. 10.1111/ijac.1399910.1111/ijac.13999 ↗
4. 10.1002/jbm.b.3288910.1002/jbm.b.32889 ↗
5. 10.1080/21691401.2018.155378510.1080/21691401.2018.1553785 ↗
6. 10.1007/s40883-020-00178-810.1007/s40883-020-00178-8 ↗
7. 10.1007/s40883-020-00151-510.1007/s40883-020-00151-5 ↗
8. 10.1007/s40883-016-0013-810.1007/s40883-016-0013-8 ↗
9. 10.1007/s40883-015-0005-010.1007/s40883-015-0005-0 ↗
10. 10.1007/s40883-021-00225-y10.1007/s40883-021-00225-y ↗
11. 10.1016/j.engreg.2021.12.00310.1016/j.engreg.2021.12.003 ↗
12. 10.1007/s40883-018-0076-910.1007/s40883-018-0076-9 ↗
13. 10.1002/adfm.20109007310.1002/adfm.201090073 ↗
14. 10.1557/s43578-022-00551-z10.1557/s43578-022-00551-z ↗
15. 10.1002/jor.2127610.1002/jor.21276 ↗
16. 10.1126/scitranslmed.300440410.1126/scitranslmed.3004404 ↗
17. 10.1007/s40883-022-00278-710.1007/s40883-022-00278-7 ↗
18. 10.1166/jbt.2013.110710.1166/jbt.2013.1107 ↗
19. 10.1016/j.actbio.2013.07.00310.1016/j.actbio.2013.07.003 ↗
20. 10.1002/pat.326610.1002/pat.3266 ↗
21. 10.1016/j.drudis.2014.01.01210.1016/j.drudis.2014.01.012 ↗
22. 10.1371/journal.pone.010162710.1371/journal.pone.0101627 ↗
23. 10.2174/15680260878379097410.2174/156802608783790974 ↗
24. 10.1007/s12598-015-0446-010.1007/s12598-015-0446-0 ↗
25. 10.1166/jnn.2016.1273810.1166/jnn.2016.12738 ↗
26. 10.1016/j.addr.2016.04.01510.1016/j.addr.2016.04.015 ↗
27. 10.1007/s10965-022-03397-510.1007/s10965-022-03397-5 ↗
28. 10.1002/jcp.2807810.1002/jcp.28078 ↗
29. 10.1002/jcp.2769710.1002/jcp.27697 ↗
30. 10.1177/0022034521101043610.1177/00220345211010436 ↗
31. 10.1002/jcp.2780710.1002/jcp.27807 ↗
32. 10.1016/j.biomaterials.2008.09.06510.1016/j.biomaterials.2008.09.065 ↗
33. 10.1089/ten.teb.2015.010010.1089/ten.teb.2015.0100 ↗
34. 10.1111/jav.0071410.1111/jav.00714 ↗
35. 10.1016/j.ijpharm.2011.02.04110.1016/j.ijpharm.2011.02.041 ↗
36. 10.1007/s40883-021-00226-x10.1007/s40883-021-00226-x ↗
37. 10.1152/ajpheart.00171.200310.1152/ajpheart.00171.2003 ↗
38. 10.1073/pnas.111356010910.1073/pnas.1113560109 ↗
39. 10.1007/s00424-020-02482-210.1007/s00424-020-02482-2 ↗
40. 10.1081/BIO-20004665910.1081/BIO-200046659 ↗
41. 10.1016/S0167-7799(98)01205-010.1016/S0167-7799(98)01205-0 ↗
42. 10.1126/science.106844310.1126/science.1068443 ↗
43. 10.1002/adma.20170142910.1002/adma.201701429 ↗
44. 10.7150/thno.4503510.7150/thno.45035 ↗
45. 10.1016/j.cej.2017.10.03210.1016/j.cej.2017.10.032 ↗
46. 10.1089/wound.2018.088710.1089/wound.2018.0887 ↗
47. 10.1021/acsami.5b1121610.1021/acsami.5b11216 ↗
48. 10.1016/j.ceramint.2020.01.21010.1016/j.ceramint.2020.01.210 ↗
49. 10.3390/ijms2308436510.3390/ijms23084365 ↗
50. 10.1021/acsnano.7b0100610.1021/acsnano.7b01006 ↗
51. 10.1016/j.tibtech.2021.01.00710.1016/j.tibtech.2021.01.007 ↗
52. 10.1186/s12951-020-00641-210.1186/s12951-020-00641-2 ↗
53. 10.1038/nrd130710.1038/nrd1307 ↗
54. 10.1007/s10856-015-5542-z10.1007/s10856-015-5542-z ↗
55. 10.1039/C5TB02635K10.1039/C5TB02635K ↗
56. 10.1155/2013/90935410.1155/2013/909354 ↗
57. 10.1039/D0TB00885K10.1039/D0TB00885K ↗
58. 10.1038/s41427-019-0166-210.1038/s41427-019-0166-2 ↗
59. 10.1016/S0304-3894(99)00051-510.1016/S0304-3894(99)00051-5 ↗
60. 10.1088/1748-605X/abd1b810.1088/1748-605X/abd1b8 ↗
61. 10.1016/j.ijbiomac.2019.04.15910.1016/j.ijbiomac.2019.04.159 ↗
62. 10.1016/j.ceramint.2018.09.24710.1016/j.ceramint.2018.09.247 ↗
63. 10.1002/jbm.a.3687910.1002/jbm.a.36879 ↗
64. 10.1016/j.colsurfb.2020.11137610.1016/j.colsurfb.2020.111376 ↗
65. 10.1038/nrd130710.1038/nrd1307 ↗
66. 10.1016/j.ajpath.2010.12.00610.1016/j.ajpath.2010.12.006 ↗
67. 10.3109/21691401.2015.111123910.3109/21691401.2015.1111239 ↗
68. 10.1021/cr970143c10.1021/cr970143c ↗
69. 10.1021/bm400074t10.1021/bm400074t ↗
70. 10.1038/nrm173610.1038/nrm1736 ↗
71. 10.1111/j.1525-1594.2008.00698.x10.1111/j.1525-1594.2008.00698.x ↗
72. 10.1002/adhm.20160055910.1002/adhm.201600559 ↗
73. 10.1007/s00449-016-1711-910.1007/s00449-016-1711-9 ↗
74. 10.1016/j.jcis.2020.03.04610.1016/j.jcis.2020.03.046 ↗
75. 10.1182/bloodadvances.201701215310.1182/bloodadvances.2017012153 ↗
76. 10.1021/nn901146y10.1021/nn901146y ↗
77. 10.1016/j.cej.2021.12933510.1016/j.cej.2021.129335 ↗
78. 10.3390/pharmaceutics1111058310.3390/pharmaceutics11110583 ↗
79. 10.1016/j.ijpharm.2021.12081010.1016/j.ijpharm.2021.120810 ↗
80. 10.1557/adv.2016.28210.1557/adv.2016.282 ↗
81. 10.1517/14712598.4.5.65910.1517/14712598.4.5.659 ↗
82. 10.1063/1.356709710.1063/1.3567097 ↗
83. 10.1002/adma.20080309210.1002/adma.200803092 ↗
84. 10.1002/jbm.b.3446110.1002/jbm.b.34461 ↗
85. 10.1016/j.mtla.2020.10087710.1016/j.mtla.2020.100877 ↗
86. 10.3390/polym1206123310.3390/polym12061233 ↗
87. 10.1016/j.colsurfb.2021.11185010.1016/j.colsurfb.2021.111850 ↗
88. 10.1002/jbm.a.3679910.1002/jbm.a.36799 ↗
89. 10.1016/j.foodhyd.2017.08.02310.1016/j.foodhyd.2017.08.023 ↗
90. 10.1007/s10856-015-5542-z10.1007/s10856-015-5542-z ↗
91. 10.1016/j.biomaterials.2016.01.03210.1016/j.biomaterials.2016.01.032 ↗
92. 10.1016/j.actbio.2009.08.04110.1016/j.actbio.2009.08.041 ↗
93. 10.1016/j.ijpharm.2021.12090210.1016/j.ijpharm.2021.120902 ↗
94. 10.1021/acsami.8b0173610.1021/acsami.8b01736 ↗
95. 10.1016/j.jconrel.2004.07.00710.1016/j.jconrel.2004.07.007 ↗
96. 10.1016/j.jsps.2012.05.00910.1016/j.jsps.2012.05.009 ↗
97. 10.1016/j.apmt.2021.10096010.1016/j.apmt.2021.100960 ↗
98. 10.3390/app809149210.3390/app8091492 ↗
99. 10.1002/bit.2716710.1002/bit.27167 ↗
100. 10.1007/s40883-018-0074-y10.1007/s40883-018-0074-y ↗