DataVXACS Applied Materials & InterfacesPaper
journal article·2020-01-29

Highly Virulent Bactericidal Effects of Curcumin-Based μ-Cages Fabricated by Two-Photon Polymerization

Davy-Louis Versace, Gabriela Moran, Mehdi Belqat, Arnaud Spangenberg, Rachel Méallet-Renault, Samir Abbad-Andaloussi, Vlasta Brezová, Jean-Pierre Malval

ACS Applied Materials & Interfaces· Volume 12· Issue 4
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Source abstract

Abstract

A new antibacterial strategy is reported based on two-photon fabrication of three-dimensional curcumin-embedded μ-cages. Such devices were designed to entrap and kill Staphylococcus aureus bacteria upon visible light irradiation. The proposed concept mainly relies on the pivotal role of curcumin, which is sequentially used as a two-photon active free radical initiator and as a photogenerator of reactive oxygen species within the cage μ-volumes. We show that these μ-cages exhibit extremely high antimicrobial properties, leading to 95% bacteria mortality after only 10 min visible irradiation. A preconcentration mechanism of photogenerated oxygen species is proposed to account for this highly performing bactericidal effect whose virulence can be strikingly switched on by increasing the light exposure time from 5 to 10 min.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Nanoplatforms for cancer theranostics · Nonlinear Optical Materials Studies · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

ICMPE, CNRS-UPEC UMR 7182, Université Paris-Est Créteil (UPEC), 94320 Thiais, France

ISMO, CNRS, Université Paris-Saclay, Univ. Paris-Sud, Building 520, 91405 Orsay, France

IS2M, CNRS, Université Haute Alsace, 68057 Mulhouse, France

Laboratoire Eau, Environnement et Systèmes Urbains (LEESU), UMR MA 102, Université Paris-Est Créteil (UPEC), 61, avenue du general de Gaulle, 94320 Thiais, France

Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, SK-812 37 Bratislava, Slovak Republic

Funding

Agence Nationale de la Recherche · Vedeck? Grantov? Agent?ra M?VVa? SR a SAV · Ministerstvo ?kolstva, vedy, v?skumu a ?portu Slovenskej republiky · Universit? Paris-Sud · Institut de Chimie et des Mat?riaux Paris-Est

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