journal article·2019-05-08

Stretchable and Bioadhesive Supramolecular Hydrogels Activated by a One-Stone–Two-Bird Postgelation Functionalization Method

Kongchang Wei, Xiaoyu Chen, Pengchao Zhao, Qian Feng, Boguang Yang, Rui Li, Zhi-Yong Zhang, Liming Bian

ACS Applied Materials & Interfaces· Volume 11· Issue 18
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Abstract

Resembling soft tissues, stretchable hydrogels are promising biomaterials for many biomedical applications due to their excellent mechanical robustness. However, conventional stretchable hydrogels with a synthetic polymer matrix are usually bioinert. The lack of cell and tissue adhesiveness of such hydrogels limits their applications. An easy but reliable postgelation functionalization method is desirable. Herein, we report the fabrication of stretchable supramolecular hydrogels cross-linked by multivalent host-guest interactions. Such hydrogels containing thiourea ( TU) functionalities can be bioactivated with a catechol-modified peptide (Cat-RGD) via thiourea-catechol ( TU-Cat) coupling reaction. This postgelation bioactivation of the otherwise bioinert hydrogels not only conjugates bioactive ligands for cell attachment but also introduces and preserves the catechol structures for tissue adhesion. This straightforward fabrication and one-stone-two-bird bioactivation of the stretchable hydrogels may find broad applications in developing advanced soft biomaterials for tissue repair, wound dressing, and lesion sealing.
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Research context

OpenAlex topics: Hydrogels: synthesis, properties, applications · Polymer Surface Interaction Studies · Advanced Materials and Mechanics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong

Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland

Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, P. R. China

Translational Research Centre of Regenerative Medicine and 3D Printing Technologies of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Road, Liwan District, Guangzhou City, Guangdong Province, 510150, P. R. China

Translational Research Centre of Regenerative Medicine and 3D Printing Technologies of Guangzhou Medical University, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China

Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, P. R. China

Funding

National Natural Science Foundation of China · Research Grants Council, University Grants Committee · Ministry of Science and Technology of the People's Republic of China · Food and Health Bureau · Health and Medical Research Fund · Chow Yuk Ho Technology Centre for Innovative Medicine, Chinese University of Hong Kong · Guangzhou Regenerative Medicine and Health Guangdong Laboratory

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