journal article·2017-10-25

Facile Coordination-Precipitation Route to Insoluble Metal Roussin’s Black Salts for NIR-Responsive Release of NO for Anti-Metastasis

Lijuan Chen, Qianjun He, Minyi Lei, Liwei Xiong, Kun Shi, Liwei Tan, Zhaokui Jin, Tianfu Wang, Zhiyong Qian

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Abstract

A facile and general coordination-precipitation method is developed to synthesize insoluble metal Roussin’s black salts (Me-RBSs) as a new type of NIR-responsive NORMs. The weak-field ligand coordination of metal + –RBS – brings a NIR absorption effect of Me-RBSs, and further gives rise to the NIR adsorption-dependent NIR-responsive NO release profile. Intratumoral NIR-responsive release of NO effectively inhibits the growth and metastasis of the metastatic breast cancer. Aqueous insolubility of Me-RBSs ensures lower cytotoxicity and higher thermostability compared with traditional soluble RBSs. This work establishes a new class of NIR-sensitive NO donors, and may spark new inspiration for designing intelligent gas-releasing molecules.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, P. R. China

National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, Guangdong P. R. China

Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Wuhan Institute of Technology, Wuhan 430073, China

Funding

Wuhan University of Technology · National Natural Science Foundation of China · Shenzhen University · Shenzhen Basic Research Program · Shenzhen Science and Technology Innovation Committee · Sichuan Innovative Research Team Program for Young Scientists · State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology

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