DataVXACS Applied Materials & InterfacesPaper
journal article·2016-11-09

Supramolecular Self-Assemblies with Nanoscale RGD Clusters Promote Cell Growth and Intracellular Drug Delivery

Fengyang Xu, Jie Liu, Jian Tian, Linfeng Gao, Xiaju Cheng, Yue Pan, Ziling Sun, Xinming Li

ACS Applied Materials & Interfaces· Volume 8· Issue 44
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Source abstract

Abstract

In this work, we reported the generation of a novel supramolecular hydrogelator from a peptide derivative which consisted of a structural motif (e.g., Fc-FF) for supramolecular self-assembly and a functional moiety (e.g., RGD) for integrin binding. Following self-assembly in water at neutral pH, this molecule first tended to form metastable spherical aggregates, which subsequently underwent a morphological transformation to form high-aspect-ratio nanostructures over 2 h when aged at room temperature. More importantly, because of the presence of nanoscale RGD clusters on the surface of nanostructures, the self-assembled nanomaterials (e.g., nanoparticles and nanofibers) can be potentially used as a biomimetic matrix for cell culture and as a vector for cell-targeting drug delivery via multivalent RGD-integrin interactions.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Supramolecular Self-Assembly in Materials · RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

School of Biology and Basic Medical Science, Soochow University, Suzhou 215123, China

State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China

Funding

Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · State Key Laboratory of Molecular Engineering of Polymers, Fudan University · Priority Academic Program Development of Jiangsu Higher Education Institutions

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