journal article·2022-09-21

Inhibition of Bacteria In Vitro and In Vivo by Self-Assembled DNA-Silver Nanocluster Structures

Shima Liu, Qinglong Yan, Shuting Cao, Lihua Wang, Shi-Hua Luo, Min Lv

ACS Applied Materials & Interfaces· Volume 14· Issue 37
Publisher page

Abstract

Antimicrobial nanomaterials hold great promise for bacteria-infected wound healing. However, it remains a challenge to balance antimicrobial efficacy and biocompatibility for these artificial antimicrobials. Here we employed biocompatible genetic molecule DNA as a building material to fabricate antimicrobial materials, including self-assembled Y-shaped DNA-silver nanocluster composite (Y-Ag) and Y-Ag hydrogel (Y-Ag-gel). We demonstrate that macroscopic and microcosmic DNA-Ag composites can effectively inhibit bacterial growth but do not affect cell proliferation in vitro. In particular, Y-Ag spray can speed up the process of wound healing in vivo. Considering the efficacy and advantages of DNA-based materials, our findings provide a promising route to fabricate a novel wound dressing such as spray and hydrogel for therapeutic wound healing.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanocluster Synthesis and Applications · Advanced biosensing and bioanalysis techniques · Antimicrobial Peptides and Activities

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

Key Laboratory of Hunan Forest Products and Chemical Industry Engineering, Jishou University, Hunan 416000, China

The Interdisciplinary Research Center, Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China

University of Chinese Academy of Sciences, Beijing 10049, China

Department of Traumatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China

Funding

Natural Science Foundation of?Hunan Province · National Natural Science Foundation of China

References (51)

Show source-provided references
1. 10.1016/j.biomaterials.2017.05.01110.1016/j.biomaterials.2017.05.011 ↗
2. 10.1002/adhm.20210047710.1002/adhm.202100477 ↗
3. 10.1146/annurev-bioeng-010220-11300810.1146/annurev-bioeng-010220-113008 ↗
4. 10.1126/science.aaf426810.1126/science.aaf4268 ↗
5. 10.3389/fmicb.2022.87010410.3389/fmicb.2022.870104 ↗
6. 10.1002/adma.20180483810.1002/adma.201804838 ↗
7. 10.1093/femsre/fux00310.1093/femsre/fux003 ↗
8. 10.1021/cr300288v10.1021/cr300288v ↗
9. 10.1002/anie.20191639010.1002/anie.201916390 ↗
10. 10.1038/s41570-018-0015-910.1038/s41570-018-0015-9 ↗
11. 10.1016/0022-5193(82)90002-910.1016/0022-5193(82)90002-9 ↗
12. 10.1021/ar500108210.1021/ar5001082 ↗
13. 10.1126/science.126090110.1126/science.1260901 ↗
14. 10.1038/s41596-021-00621-210.1038/s41596-021-00621-2 ↗
15. 10.1021/acs.accounts.6b0052410.1021/acs.accounts.6b00524 ↗
16. 10.1039/C8CS00011E10.1039/C8CS00011E ↗
17. 10.1016/j.nantod.2019.10076710.1016/j.nantod.2019.100767 ↗
18. 10.1021/acs.accounts.8b0036610.1021/acs.accounts.8b00366 ↗
19. 10.1021/ja031931o10.1021/ja031931o ↗
20. 10.1021/jacs.5b0533810.1021/jacs.5b05338 ↗
21. 10.1021/nn300245510.1021/nn3002455 ↗
22. 10.1002/adma.20070238010.1002/adma.200702380 ↗
23. 10.1002/adfm.20170409210.1002/adfm.201704092 ↗
24. 10.1007/s00604-020-04591-210.1007/s00604-020-04591-2 ↗
25. 10.1016/j.trac.2019.11578610.1016/j.trac.2019.115786 ↗
26. 10.3390/molecules2613404510.3390/molecules26134045 ↗
27. 10.1021/acs.analchem.8b0449310.1021/acs.analchem.8b04493 ↗
28. 10.1002/smll.20180018510.1002/smll.201800185 ↗
29. 10.1002/cjoc.20200057510.1002/cjoc.202000575 ↗
30. 10.1002/smll.20140204410.1002/smll.201402044 ↗
31. 10.1002/anie.20120592310.1002/anie.201205923 ↗
32. 10.1021/acsami.6b0067010.1021/acsami.6b00670 ↗
33. 10.1021/acsami.1c0575110.1021/acsami.1c05751 ↗
34. 10.1002/smll.20130005510.1002/smll.201300055 ↗
35. 10.1002/smll.20210764010.1002/smll.202107640 ↗
36. 10.1126/science.aaf362710.1126/science.aaf3627 ↗
37. 10.1021/acsami.2c0476910.1021/acsami.2c04769 ↗
38. 10.1002/advs.20170052710.1002/advs.201700527 ↗
39. 10.1002/adhm.20170099810.1002/adhm.201700998 ↗
40. 10.1021/acsami.9b0226510.1021/acsami.9b02265 ↗
41. 10.1021/acsami.1c1444510.1021/acsami.1c14445 ↗
42. 10.1021/acsami.0c1450910.1021/acsami.0c14509 ↗
43. 10.1002/adma.20100334310.1002/adma.201003343 ↗
44. 10.1039/C6BM00717A10.1039/C6BM00717A ↗
45. 10.1055/s-0042-11338310.1055/s-0042-113383 ↗
46. 10.1007/s00284-017-1235-910.1007/s00284-017-1235-9 ↗
47. 10.3390/ijms2016395410.3390/ijms20163954 ↗
48. 10.1002/adfm.20130420210.1002/adfm.201304202 ↗
49. 10.1016/j.biomaterials.2018.08.04410.1016/j.biomaterials.2018.08.044 ↗
50. 10.1038/s41551-018-0317-810.1038/s41551-018-0317-8 ↗
51. 10.1021/acsnano.1c0938810.1021/acsnano.1c09388 ↗