journal article·2019-10-09

Synergy of CO2 Response and Aggregation-Induced Emission in a Block Copolymer: A Facile Way To “See” Cancer Cells

Yao Li, Xin Wu, Bin Yang, Xiaokai Zhang, Hao Li, Ahmad Umar, Nicolaas Frans de Rooij, Guofu Zhou, Yao Wang

ACS Applied Materials & Interfaces· Volume 11· Issue 40
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Abstract

Carbon dioxide (CO2), an important gas molecule metabolite produced by the tricarboxylic acid cycle, is a direct signal for identifying cancers in cells and tissues. Herein, design and synthesis of a novel “breathable” block polymer supramolecular assembly probe consisting of a hydrophilic block, an amidine-containing CO2-responsive block, and an aggregation-induced emission (AIE) luminescence block to detect CO2 metabolized by cancer cells is reported. The triblock copolymer poly-(4-undecoxy tetraphenyl ethylene methacrylate)-b-poly-((N-amidino)-(2,3-dihydro-1H-1, 4-methyl-1, 2,3-triazole)-(ethenylbenzene))-b-poly(ethylene oxide) (PTPE-b-PAD-b-PEO) was successfully synthesized and characterized. This triblock copolymer could be self-assembled into “breathable” aqueous solution vesicles. In the presence of CO2, the amidine-containing CO2-responsive block (PAD block) of the vesicle “inhales” an amount of CO2, which causes the volume of the vesicle to expand. The expansion of the vesicle induces the aggregation of the AIE luminescence block (PTPE block), which resulted in the fluorescence intensity enhancement. The supramolecular vesicles “exhale” CO2, and the volume and AIE phenomenon of the vesicles decrease when N2 is passed into the solution. On the basis of this reversible change of fluorescence intensity, HeLa cervical cancer cells, CNE1 nasopharynx cancer cells, 5-8F nasopharynx cancer cells, 16HBE human bronchial epithelial cells, and GES-1 human gastric mucosa epithelial cells have all been successfully detected and identified.
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Research context

OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Luminescence and Fluorescent Materials · Covalent Organic Framework Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, P. R. China

Liaoning Province Key Laboratory of Pulp and Papermaking Engineering, Dalian Polytechnic University, Dalian, Liaoning Province 116034, P. R. China

Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing 100191, P. R. China

The Sixth Affiliated Hospital; Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China

Department of Chemistry, Faculty of Science and Arts and Promising Centre for Sensors and Electronic Devices, Najran University, Najran 11001, Kingdom of Saudi Arabia

Funding

State Administration of Foreign Experts Affairs · Ministry of Education of the People's Republic of China · National Natural Science Foundation of China · South China Normal University · Ministry of Education - Kingdom of Saudi Arabi · Education Bureau of Guangdong Province · Guangdong Provincial Key Laboratory of Optical Information Materials and Technology, South China Acadamy of Advanced Optoelectronics, South China Normal University

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