DataVXACS Applied Materials & InterfacesPaper
journal article·2019-07-17

Hollow Microcapsules with Ulcerative Colitis Therapeutic Effects Made of Multifunctional Turkish Galls Extraction

Xing Zhang, Jie Zang, Shangzhi Ma, Wei Yu, Fei Long, Rong Qi, Gang Guo, Liangxue Zhou, Bo Han

ACS Applied Materials & Interfaces· Volume 11· Issue 28
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Source abstract

Abstract

Ulcerative colitis (UC) has been listed as one of the refractory diseases of modern society by the World Health Organization. Our previous studies found that Turkish galls Gallotannins (TGTs) have a significant effect on anti-UC. Here, TGTs were extracted using a simple method and TGTs-FeIII microcapsules were prepared by a self-assembly technique. Microcapsules were characterized by liquid chromatography–mass spectrometry, scanning electron microscopy, and so forth. The results verified that hollow spheres of TGTs-FeIII microcapsules were successfully prepared. It is interesting that microcapsules were more likely to accumulate on the inflammatory surface from ex vivo and in vivo adhesion experiments, and effectively alleviate UC symptoms. This study will provide valuable insight into the development of safe and efficient drug delivery system platforms for further biomedical usages.
Source: openalex_inverted_index · Quality: baseline

Research context

Ceramics & glasses

OpenAlex topics: Essential Oils and Antimicrobial Activity · Phytochemicals and Antioxidant Activities · Pomegranate: compositions and health benefits

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education, Shihezi University College of Pharmacy, Shihezi 832003, P. R. China

Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Institute of Cardiovascular Sciences Peking University Health Science Center, 38 Xueyuan Rode, Beijing 100191, P. R. China

State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, West China Hospital, Sichuan University—Collaborative Innovation Center for Biotherapy, Chengdu 610041, P. R. China

Funding

Shihezi University · National Natural Science Foundation of China · Xinjiang Production and Construction Corps

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