Carbon Nanoparticles Trapped in Vivo—Similar to Carbon Nanotubes in Time-Dependent Biodistribution
Source abstract
Abstract
Carbon nanoparticles are in all of the carbon nanomaterials that are presently widely pursued for potential bioapplications, but their in vivo biodistribution-related properties are largely unknown. In this work, highly (13)C-enriched carbon nanoparticles were prepared to allow their quantification in biological samples by using isotope-ratio mass spectroscopy. The in vivo biodistribution results are presented and discussed, and also compared with those of the aqueous suspended carbon nanotubes reported previously. The distribution profile and time dependencies are largely similar between the nanoparticles and nanotubes, with results on both suggesting meaningful accumulation in some major organs over an extended period of time. Therefore, the surface modification of carbon nanoparticles, preferably the chemical functionalization of the nanoparticles with biocompatible molecules or species, is desirable or necessary in the pursuit of these nanomaterials for various bioapplications.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Carbon and Quantum Dots Applications · Graphene and Nanomaterials Applications · Nanocluster Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China
Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China
Department of Chemistry and Laboratory for Emerging Materials and Technology, Clemson University, Clemson, South Carolina 29634-0973, United States, and
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Funding
Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · National Science Foundation
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