DataVXACS Applied Materials & InterfacesPaper
journal article·2022-12-14

Strong Biopolymer-Based Nanocomposite Hydrogel Adhesives with Removability and Reusability for Damaged Tissue Closure and Healing

Yu Tian, Pengfei Guan, Chaoyao Wen, Manjia Lu, Tong Li, Lei Fan, Qinfeng Yang, Youjun Guan, Xinchang Kang, Yuhe Jiang, Chengyun Ning, Rumin Fu, Guoxin Tan, Lei Zhou

ACS Applied Materials & Interfaces· Volume 14· Issue 49
Publisher page
Source abstract

Abstract

Bioadhesives are widely used in a variety of medical settings due to their ease of use and efficient wound closure and repair. However, achieving both strong adhesion and removability/reusability is highly needed but challenging. Here, we reported an injectable mesoporous bioactive glass nanoparticle (MBGN)-incorporated biopolymer hydrogel bioadhesive that demonstrates a strong adhesion strength (up to 107.55 kPa) at physiological temperatures that is also removable and reusable. The incorporation of MBGNs in the biopolymer hydrogel significantly enhances the tissue adhesive strength due to an increased cohesive and adhesive property compared to the hydrogel adhesive alone. The detachment of bioadhesive results from temperature-induced weakening of interfacial adhesive strength. Moreover, the bioadhesive displays injectability, self-healing, and excellent biocompatibility. We demonstrate potential applications of the bioadhesive in vitro, ex vivo, and in vivo for hemostasis and intestinal leakage closure and accelerated skin wound healing compared to surgical wound closures. This work provides a novel design of strong and removable bioadhesives.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersCeramics & glassesNanomaterialsBiomaterials

OpenAlex topics: Surgical Sutures and Adhesives · Wound Healing and Treatments · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, P. R. China

Department of Pediatric Orthopedic, Center for Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510515, P. R. China

Division of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P. R. China

Department of Computational Biology, Stony Brook University, Stony Brook, New York 11794, United States

School of Materials Science and Engineering & National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, P. R. China

Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, Department of Spine Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, P. R. China

Funding

Guangzhou Science and Technology Program key projects · National Natural Science Foundation of China · Foshan City

References (35)

Show source-provided references
1. 10.1016/j.nantod.2020.10104910.1016/j.nantod.2020.101049 ↗
2. 10.1016/j.cej.2022.13727210.1016/j.cej.2022.137272 ↗
3. 10.1038/s41578-019-0171-710.1038/s41578-019-0171-7 ↗
4. 10.1021/acs.chemrev.1c0081510.1021/acs.chemrev.1c00815 ↗
5. 10.1016/j.bioactmat.2022.05.01710.1016/j.bioactmat.2022.05.017 ↗
6. 10.1073/pnas.200638911710.1073/pnas.2006389117 ↗
7. 10.1002/adma.20210932510.1002/adma.202109325 ↗
8. 10.1073/pnas.220307411910.1073/pnas.2203074119 ↗
9. 10.1073/pnas.181853411610.1073/pnas.1818534116 ↗
10. 10.1002/adma.20200766310.1002/adma.202007663 ↗
11. 10.1002/adfm.20200709910.1002/adfm.202007099 ↗
12. 10.1002/adfm.20220110810.1002/adfm.202201108 ↗
13. 10.1002/adma.20180694810.1002/adma.201806948 ↗
14. 10.1021/acsnano.2c0066210.1021/acsnano.2c00662 ↗
15. 10.1002/admt.20200067610.1002/admt.202000676 ↗
16. 10.1038/s41467-021-24022-x10.1038/s41467-021-24022-x ↗
17. 10.1039/C9MH01255A10.1039/C9MH01255A ↗
18. 10.1021/jacs.9b0105610.1021/jacs.9b01056 ↗
19. 10.1038/s41467-021-27529-510.1038/s41467-021-27529-5 ↗
20. 10.1002/adfm.20200745710.1002/adfm.202007457 ↗
21. 10.1016/j.bioactmat.2021.11.00810.1016/j.bioactmat.2021.11.008 ↗
22. 10.1021/acsami.2c0840010.1021/acsami.2c08400 ↗
23. 10.1016/j.bioactmat.2020.09.01210.1016/j.bioactmat.2020.09.012 ↗
24. 10.1039/D1GC03472C10.1039/D1GC03472C ↗
25. 10.1016/j.cej.2019.03.20810.1016/j.cej.2019.03.208 ↗
26. 10.1002/advs.20140001010.1002/advs.201400010 ↗
27. 10.1002/adfm.20200440710.1002/adfm.202004407 ↗
28. 10.1021/acsami.7b0908310.1021/acsami.7b09083 ↗
29. 10.3390/nano1211187410.3390/nano12111874 ↗
30. 10.3390/polym1314231910.3390/polym13142319 ↗
31. 10.1016/j.bioactmat.2021.05.03910.1016/j.bioactmat.2021.05.039 ↗
32. 10.1126/scitranslmed.aba801410.1126/scitranslmed.aba8014 ↗
33. 10.1016/j.nantod.2022.10146710.1016/j.nantod.2022.101467 ↗
34. 10.1039/D0TB02000A10.1039/D0TB02000A ↗
35. 10.1002/adfm.20180911010.1002/adfm.201809110 ↗