A Facile and Universal Method to Efficiently Fabricate Diverse Protein Capsules for Multiple Potential Applications

Pengzhong Shi; Jianghui Qin; Xiaoxiao Wu; Liwen Wang; Tinghong Zhang; Dejun Yang; Xingjie Zan; Dietmar Appelhans

doi:10.1021/acsami.9b15019

journal article·2019-10-23

A Facile and Universal Method to Efficiently Fabricate Diverse Protein Capsules for Multiple Potential Applications

Pengzhong Shi, Jianghui Qin, Xiaoxiao Wu, Liwen Wang, Tinghong Zhang, Dejun Yang, Xingjie Zan, Dietmar Appelhans

ACS Applied Materials & Interfaces· Volume 11· Issue 42

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Source abstract

Abstract

Proteins are considered to be one of the most important highly reproducible and monodisperse building blocks with specific functions in life sciences and material science. Protein capsules and their hybrids composed of protein–polymer conjugates have been intensively explored in drug delivery, catalysis, and cell-mimicking functions. Herein, we present a facile, universal, and efficient method to fabricate the diverse protein capsules, independent of the molecular weight (Mw), isoelectric points (IEP), wettability, amino acid sequence, and functional domains of enumerated proteins. The protein capsules were well characterized by various techniques. Furthermore, their ability to store the original protein functionality was demonstrated, which was mainly embodied in their enzyme responsiveness and good biocompatibility in vitro and in vivo. We believe that these protein capsules have multiple potential applications such as in drug delivery, tissue engineering, catalysis, and other application fields.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Biomaterials Catalysis & surfaces

OpenAlex topics: Enzyme Catalysis and Immobilization · Polymer Surface Interaction Studies · Proteins in Food Systems

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, P. R. China

Wenzhou Institute of Biomaterials and Engineering, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang Province 325001, P. R. China

Engineering Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province, Wenzhou Institute of Biomaterials and Engineering, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang Province 325001, P. R. China

Leibniz Institute of Polymer Research Dresden, Hohe Strasse 6, Dresden 01069, Germany

Funding

Wenzhou Municipal Science and Technology Bureau · National Natural Science Foundation of China · Wenzhou Municipality

References (50)

Show source-provided references

1. 10.1038/nrd239910.1038/nrd2399 ↗

2. 10.2337/diabetes.37.12.159510.2337/diabetes.37.12.1595 ↗

3. 10.1038/nrc323610.1038/nrc3236 ↗

4. 10.1038/nature1932310.1038/nature19323 ↗

5. 10.1038/nature1111710.1038/nature11117 ↗

6. 10.1039/C6SM02520J10.1039/C6SM02520J ↗

7. 10.1021/acsami.8b1121610.1021/acsami.8b11216 ↗

8. 10.1021/acsnano.8b0258810.1021/acsnano.8b02588 ↗

9. 10.1038/nnano.2012.22010.1038/nnano.2012.220 ↗

10. 10.1002/adma.20110289010.1002/adma.201102890 ↗

11. 10.1039/C7SC05086K10.1039/C7SC05086K ↗

12. 10.1016/j.msec.2019.02.06310.1016/j.msec.2019.02.063 ↗

13. 10.7150/thno.3347210.7150/thno.33472 ↗

14. 10.1016/j.addr.2011.03.01310.1016/j.addr.2011.03.013 ↗

15. 10.1016/j.jconrel.2006.06.01610.1016/j.jconrel.2006.06.016 ↗

16. 10.1016/j.addr.2011.03.01610.1016/j.addr.2011.03.016 ↗

17. 10.1002/smll.20109005510.1002/smll.201090055 ↗

18. 10.1039/b9nr00341j10.1039/b9nr00341j ↗

19. 10.1016/j.addr.2011.05.00710.1016/j.addr.2011.05.007 ↗

20. 10.1021/la901243m10.1021/la901243m ↗

21. 10.1002/smll.20190035010.1002/smll.201900350 ↗

22. 10.1038/ncomms323910.1038/ncomms3239 ↗

23. 10.1021/ja504213m10.1021/ja504213m ↗

24. 10.1039/C3CS60376H10.1039/C3CS60376H ↗

25. 10.1039/C7CC04180B10.1039/C7CC04180B ↗

26. 10.1016/j.bbrc.2006.12.22310.1016/j.bbrc.2006.12.223 ↗

27. 10.1016/j.biomaterials.2009.01.02710.1016/j.biomaterials.2009.01.027 ↗

28. 10.1021/bm801502r10.1021/bm801502r ↗

29. 10.1002/adma.20150224310.1002/adma.201502243 ↗

30. 10.1002/adma.20110223410.1002/adma.201102234 ↗

31. 10.1021/la047083810.1021/la0470838 ↗

32. 10.1038/s41563-018-0183-510.1038/s41563-018-0183-5 ↗

33. 10.1002/adma.20060194710.1002/adma.200601947 ↗

34. 10.1039/C8TB00312B10.1039/C8TB00312B ↗

35. 10.1016/j.colsurfb.2018.11.07910.1016/j.colsurfb.2018.11.079 ↗

36. 10.1016/0165-022X(95)00039-T10.1016/0165-022X(95)00039-T ↗

37. 10.1016/0031-9422(91)83426-L10.1016/0031-9422(91)83426-L ↗

38. 10.1016/S0142-9612(96)00202-510.1016/S0142-9612(96)00202-5 ↗

39. 10.1021/la036177z10.1021/la036177z ↗

40. 10.1007/BF0334838010.1007/BF03348380 ↗

41. 10.1021/jf60228a02010.1021/jf60228a020 ↗

42. 10.1016/0304-4165(79)90225-310.1016/0304-4165(79)90225-3 ↗

43. Pantoja-Castro M. A. · Rev. Latinoam. Quím. · 2011 · 39 · 107

44. 10.1016/j.colsurfa.2005.03.01710.1016/j.colsurfa.2005.03.017 ↗

45. 10.1021/acs.macromol.6b0210610.1021/acs.macromol.6b02106 ↗

46. 10.1055/s-0032-131718210.1055/s-0032-1317182 ↗

47. 10.1016/S0040-4020(99)00809-110.1016/S0040-4020(99)00809-1 ↗

48. 10.1021/ja513058h10.1021/ja513058h ↗

49. 10.1021/acsami.5b0326310.1021/acsami.5b03263 ↗

50. 10.1002/adfm.20070041610.1002/adfm.200700416 ↗