DataVXACS Applied Materials & InterfacesPaper
journal article·2018-10-03

Intracellular near-Infrared Microlaser Probes Based on Organic Microsphere–SiO2 Core–Shell Structures for Cell Tagging and Tracking

Zheng Lv, Zhongwei Man, Zhenzhen Xu, Changfu Feng, Yong Yang, Qing Liao, Xu Wang, Lemin Zheng, Hongbing Fu

ACS Applied Materials & Interfaces· Volume 10· Issue 39
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Source abstract

Abstract

Conventional near-infrared (NIR) luminescent probes, such as DsRed and Cy5, utilize spontaneous emission (SE) signals, which are broad (fwhm >50 nm) and often have low quantum yield. Herein, we developed smart NIR intracellular whispering-gallery mode (WGM) microlaser probes made by organic microspheres of (E)-3-(4-(diptolylamino)phenyl)-1-(1-hydroxynaphthalen-2-yl)prop-2-en-1-one (DPHP) coated with a silica shell. The overall small diameter (D, adjustable between 2 and 10 μm) and the biocompatible silica shell ensure our core–shell microspheres (CSmSPs) to be engulfed in cells as a microlaser operating around 720 nm with a low threshold of 0.78 μJ/cm2. Considering that WGM mode spacing depending strongly on its size, it will be possible to distinguish millions of individual macrophages through well-defined WGM lasing peaks (fwhm ≤2 nm) of CSmSPs of different sizes. Furthermore, we monitored the transformation of normal macrophages to foamy ones by encoding them with our NIR CSmSPs microlaser probes, which deliver constant WGM lasing signals with a spectral fluctuation <0.02 nm and excellent stability.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing Key Laboratory for Optical Materials and Photonic Devices, Department of Chemistry, Capital Normal University, Beijing 100048, P. R. China

Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of Chemistry, School of Sciences, Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, People’s Republic of China

School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, the Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, Peking University Health Science Center, Beijing 100191, P. R. China

Funding

Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China · Capital Normal University · Capacity Building for Sci-Tech Innovation · Beijing Advanced Innovation Center for Imaging Technology, Capital Normal University

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