DataVXACS Applied Materials & InterfacesPaper
journal article·2017-10-04

MicroRNA-Catalyzed Cancer Therapeutics Based on DNA-Programmed Nanoparticle Complex

Xucheng Luo, Zhi Li, Ganglin Wang, Xuewen He, Xiaoqin Shen, Quanhong Sun, Li Wang, Renye Yue, Nan Ma

ACS Applied Materials & Interfaces· Volume 9· Issue 39
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Source abstract

Abstract

The use of cancer-relevant microRNA molecules as endogenous drug release stimuli is promising for personalized cancer treatment yet remains a great challenge because of their low abundance. Herein, we report a new type of microRNA-catalyzed drug release system based on DNA-programmed gold nanoparticle (GNP)-quantum dot (QD) complex. We show that a trace amount of miRNA-21 molecules could specifically catalyze the disassembly of doxorubicin (Dox)-loaded GNP-QDs complex through entropy driven process, during which the Dox-intercalating sites are destructed for drug release. This catalytic reaction could proceed both in fixed cells and live cells with miRNA-21 overexpression. Dox molecules could be efficiently released in the cells and translocate to cell nuclei. QD photoluminescence is simultaneously activated during catalytic disassembly process, thus providing a reliable feedback for microRNA-triggered drug release. The GNP-QDs-Dox complex exhibits much higher drug potency than free Dox molecules, and therefore represents a promising platform for accurate and effective cancer cell treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: MicroRNA in disease regulation · Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Institute for Advanced Study, State Key Laboratory of Neuroscience, Division of Biomedical Engineering, and Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong P. R. China

HKUST-Shenzhen Research Institute, Shenzhen 518057, P. R. China

Funding

Ministry of Science and Technology of the People's Republic of China · Soochow University · National Natural Science Foundation of China · Central People's Government of the People's Republic of China · Priority Academic Program Development of Jiangsu Higher Education Institutions

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