journal article·2014-08-27

Logic Nanoparticle Beacon Triggered by the Binding-Induced Effect of Multiple Inputs

Jing Yang, Chen Dong, Yafei Dong, Shi Liu, Linqiang Pan, Cheng Zhang

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Abstract

Recently, the toehold-mediated DNA strand displacement reaction has been widely used in detecting molecular signals. However, traditional strand displacement, without cooperative signaling among DNA inputs, is insufficient for the design of more complicated nanodevices. In this work, a logic computing system is established using the cooperative "binding-induced" mechanism, based on the AuNP-based beacons, in which five kinds of multiple-input logic gates have been constructed. This system can recognize DNA and protein streptavidin simultaneously. Finally, the manipulations of the logic system are also demonstrated by controlling programmed conjugate DNA/AuNP clusters. This study provides the possibility of detecting multiple input signals and designing complex nanodevices that can be potentially applied to the detection of multiple molecular targets and the construction of large-scale DNA-based computation.
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Molecular Junctions and Nanostructures · Biosensors and Analytical Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Control and Computer Engineering, North China Electric Power University, Beijing 102206, China

College of Life Science, Shannxi Normal University, Xi’an 710062, China

Institute of Software, School of Electronics Engineering and Computer Science, Key Laboratory of High Confidence Software Technologies of Ministry of Education, Peking University, Beijing 100871, China

Key Laboratory of Image Information Processing and Intelligent Control, School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China

Funding

State Administration of Foreign Experts Affairs · Ministry of Education of the People's Republic of China · National Natural Science Foundation of China · Beijing Excellent Talent Training Project

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