Triplet Tellurophene-Based Semiconducting Polymer Nanoparticles for Near-Infrared-Mediated Cancer Theranostics
Source abstract
Abstract
Semiconducting polymer (SP) nanoparticles (NPs) have recently emerged as one of the most promising agents for photoacoustic imaging (PAI)-guided photothermal/photodynamic therapy (PTT/PDT). Herein, a triplet tellurophene-based SP (PNDI-2T) was synthesized with efficient tin-free direct heteroarylation polycondensation. The PNDI-2T NPs display remarkable near-infrared absorption and low cytotoxicity. In addition, PNDI-2T NPs can generate abundant reactive oxygen species (ROS) since tellurophene facilitates the intersystem crossing to generate triplet excited states. Remarkably, PNDI-2T NPs present a high photothermal conversion efficiency (η = 45%) and a high ROS yield (ΦΔ = 38.7%) under 808 nm laser irradiation. Furthermore, we showed that PNDI-2T NPs could be excellent PAI-guided PTT/PDT agents for cancer theranostics. This study provides a new route to developing highly efficient and low cytotoxic agents for PAI-guided PTT/PDT.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Polydiacetylene-based materials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Materials Science and Opto-Electronic Technology & Center of Materials Science and Optoelectronics Engineering & CAS Center for Excellence in Topological Quantum Computation & CAS Key Laboratory of Vacuum Physic, University of Chinese Academy of Sciences, Beijing 100049, P. R. China
Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, People’s Republic of China
Funding
Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Chinese Academy of Sciences · China Aerospace Science and Technology Corporation
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