DataVXACS Applied Materials & InterfacesPaper
journal article·2019-04-03

Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws

Zhiru Wang, Weiwei Qin, Jialang Zhuang, Minhao Wu, Qian Li, Chunhai Fan, Yuanqing Zhang

ACS Applied Materials & Interfaces· Volume 11· Issue 13
Publisher page
Source abstract

Abstract

Synergy represents a natural approach for high-efficiency recognition in biological systems. Inspired by the recognition mechanism of viral infection of mammalian cells, here we develop heterovalency magnetic DNA nanoclaws with octopus arms morphology for synergetic cell capture. We demonstrated that the rigid-flexible DNA nanoclaws can load multiple antibodies (Abs) targeting different epitopes for enhanced capture of cancer cells, especially significantly increasing the capture efficiency of MDA-MB-231 cells up to 82.3 ± 7.1%. We also employed DNA nanoclaws with the combined use of multiple Abs to capture circulating tumor cells from clinical samples with high efficiency and specificity. We expect that the DNA nanoclaws not only could play a key role in liquid biopsy, but also could be expanded, with more applications benefiting from their modularity and programmability to modify various functionalities in future.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Bacteriophages and microbial interactions · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

College of Materials and Energy, South China Agriculatural University, Guangzhou 510642, China

Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou 510080, China

Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Ministry of Science and Technology of the People's Republic of China

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