Porous Graphene Oxide Enhanced Aptamer Specific Circulating-Tumor-Cell Sensing Interface on Light Addressable Potentiometric Sensor: Clinical Application and Simulation
Source abstract
Abstract
The circulating-tumor-cell (CTC) specific aptamer is believed to be a power recognition factor to realize clinical CTC assay. However, the limited sensing range is still one of the challenges in its real application. The porous-graphene-oxide (PGO) enhanced aptamer specific CTC sensing interface is studied on the platform of light-addressable-potentiometric-sensor (LAPS) to provide a clinical available method for CTC detection. The underlying mechanism of this sensing interface on LAPS is modeled and simulated. It is confirmed to be a promising candidate for CTC assay by the linear responding for 5-5000 spiked cells, as well as the satisfactory sensitivity for clinical samples.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Analytical Chemistry and Sensors · Electrochemical sensors and biosensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Electronic Information and Optical Engineering, Nankai University, Tianjin 300071, China
School of Medical Laboratory, Tianjin Medical University, Tianjin 300070, China
Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
Funding
National Natural Science Foundation of China
References (26)
Show source-provided references
1. 10.1126/science.123522610.1126/science.1235226 ↗
2. 10.1016/j.molmed.2010.07.00110.1016/j.molmed.2010.07.001 ↗
3. 10.1186/1479-5876-10-13810.1186/1479-5876-10-138 ↗
4. 10.1039/C6CS00803H10.1039/C6CS00803H ↗
5. 10.1021/nn500427710.1021/nn5004277 ↗
6. 10.1016/j.bios.2017.03.00910.1016/j.bios.2017.03.009 ↗
7. 10.1063/1.499147610.1063/1.4991476 ↗
8. 10.1021/acscombsci.7b0014610.1021/acscombsci.7b00146 ↗
9. 10.1021/acs.analchem.7b0049710.1021/acs.analchem.7b00497 ↗
10. 10.1021/ac400366b10.1021/ac400366b ↗
11. 10.1016/j.bios.2014.10.07010.1016/j.bios.2014.10.070 ↗
12. 10.1016/j.biomaterials.2011.01.00210.1016/j.biomaterials.2011.01.002 ↗
13. 10.1021/am500678310.1021/am5006783 ↗
14. 10.20964/2017.10.0610.20964/2017.10.06 ↗
15. 10.1021/acs.analchem.7b0276510.1021/acs.analchem.7b02765 ↗
16. 10.1021/acsomega.8b0107210.1021/acsomega.8b01072 ↗
17. 10.1016/j.bios.2018.06.02110.1016/j.bios.2018.06.021 ↗
18. 10.1021/acs.analchem.7b0526110.1021/acs.analchem.7b05261 ↗
19. 10.3390/s1605070110.3390/s16050701 ↗
20. 10.1016/j.bios.2017.10.01410.1016/j.bios.2017.10.014 ↗
21. 10.1021/acs.analchem.7b0332410.1021/acs.analchem.7b03324 ↗
22. 10.1002/mabi.20080011310.1002/mabi.200800113 ↗
23. 10.1021/nn102456w10.1021/nn102456w ↗
24. 10.1016/j.molonc.2015.03.01210.1016/j.molonc.2015.03.012 ↗
25. 10.1016/j.cej.2013.10.06010.1016/j.cej.2013.10.060 ↗
26. 10.1016/j.apsusc.2007.10.04910.1016/j.apsusc.2007.10.049 ↗