Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization
Source abstract
Abstract
A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (8-40 nm) and enabled biovectorization of SiO2@Fe3O4 core-shell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UV-vis, ζ-potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Iron oxide chemistry and applications · Nanoparticle-Based Drug Delivery · Minerals Flotation and Separation Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Inorganic Chemistry, University of Cologne, Greinstrasse 6, Cologne 50939, Germany
Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 128 43 Praha 2, Czech Republic
Max-Planck-Institut für Chemische Physik fester Stoffe, Nöthnitzer Strasse 40, 01187 Dresden, Germany
Lehrstuhl für Organische Chemie II, Ruhr Universität Bochum, Universitätsstrasse 150, 44801 Bochum, Germany
Department of Sciences, Faculty of Natural and Applied Science, Notre Dame University (Louaize), Zouk Mosbeh, Lebanon
Materials Chemistry & Analysis Group, The Tyndall National Institute at University College Cork, Cork, Ireland
International Research Center for Renewable Energy, Xian Jiaotong University Xian, Shaanxi 710049, PR China
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