DataVXACS Applied Materials & InterfacesPaper
journal article·2022-10-05

Ultrahighly Sensitive Sandwich-Type Electrochemical Immunosensor for Selective Detection of Tumor Biomarkers

Jingxian Li, Hongfen Yang, Ren Cai, Weihong Tan

ACS Applied Materials & Interfaces· Volume 14· Issue 39
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Source abstract

Abstract

Herein, a novel sandwich-type immunosensor was designed using Pt nanoparticle-decorated SnS 2 nanoplates (Pt@SnS 2 ) as a matrix and N,B-doped Eu MOF (N,B-Eu MOF) nanospheres as a signal amplifier. In Pt@SnS 2, Pt nanoparticles (NPs) enhance the surface electron transport capability and electrochemiluminescence (ECL) performance of SnS 2 nanoplates. The dual “antenna” effect of 5-boronoisophthalic acid (5-bop) and 5-nitroisophthalic acid (5-nop) enables the N,B-Eu MOFs to show very good ECL performance at the cathode. In the presence of the target carcinoembryonic antigen (CEA), the sandwich-type immunosensor provides specific immune responses, and the ECL signal of the immunosensor is greatly amplified by the signal probe N,B-Eu MOFs. In view of the above, the immunosensor was successfully applied for highly sensitive and selective detection of CEA with a detection limit of 0.06 pg·mL –1 . This sensor exhibits high sensitivity and specificity, excellent stability, good reproducibility, and good practicability in real human serum.
Source: openalex_inverted_index · Quality: baseline

Research context

Energy storageNanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis · Biosensors and Analytical Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Material Science and Engineering, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha 410082, China

University of Texas at Austin, Austin, Texas 78712, United States

The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China

Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

Funding

Natural Science Foundation of?Hunan Province · National Natural Science Foundation of China

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