Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications
Source abstract
Abstract
Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held together through strong electrostatic interaction, giving rise to a robust multilayer architecture with control over structural element orientation and chemical composition at nanoscale. Combined pH-controlled co-delivery of multiple therapeutic agents and photothermal therapy has been achieved by our scaffold system. The new platform technology can be generalized to produce other tissue scaffold systems and may enable potential multimodal therapeutic applications such as bone cancer managements.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Nanoplatforms for cancer theranostics · Advanced Photocatalysis Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Mechanical & Aerospace Engineering, Queens University Belfast, Belfast BT9 5AH, U.K.
Analytical and Testing Center, Sichuan University, Chengdu 610064, China
State Key Laboratory of Oral Diseases, & National Clinical Research Center for Oral Disease, & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
School of Pharmacy, Queens University Belfast, Belfast BT9 7BL, U.K.
School of Mathematics and Physics, Queens University Belfast, Belfast BT7 1NN, U.K.
Faculty Engineering and the Environment, University of Southampton, Southampton SO17 1BJ, U.K.
Funding
Engineering and Physical Sciences Research Council · Ministry of Science and Technology of the People's Republic of China · China Scholarship Council · National Natural Science Foundation of China
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