DataVXACS Applied Materials & InterfacesPaper
journal article·2017-11-29

Gold Nanocluster-Mediated Cellular Death under Electromagnetic Radiation

Anna Cifuentes-Rius, Angela Ivask, Shreya Das, Nuria Penya-Auladell, Laura Fabregas, Nicholas L. Fletcher, Zachary H. Houston, Kristofer J. Thurecht, Nicolas H. Voelcker

ACS Applied Materials & Interfaces· Volume 9· Issue 47
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Source abstract

Abstract

Gold nanoclusters (Au NCs) have become a promising nanomaterial for cancer therapy because of their biocompatibility and fluorescent properties. In this study, the effect of ultrasmall protein-stabilized 2 nm Au NCs on six types of mammalian cells (fibroblasts, B-lymphocytes, glioblastoma, neuroblastoma, and two types of prostate cancer cells) under electromagnetic radiation is investigated. Cellular association of Au NCs in vitro is concentration-dependent, and Au NCs have low intrinsic toxicity. However, when Au NC-incubated cells are exposed to a 1 GHz electromagnetic field (microwave radiation), cell viability significantly decreases, thus demonstrating that Au NCs exhibit specific microwave-dependent cytotoxicity, likely resulting from localized heating. Upon i.v. injection in mice, Au NCs are still present at 24 h post administration. Considering the specific microwave-dependent cytotoxicity and low intrinsic toxicity, our work suggests the potential of Au NCs as effective and safe nanomedicines for cancer therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanocluster Synthesis and Applications · Gold and Silver Nanoparticles Synthesis and Applications · Carbon and Quantum Dots Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes Campus, Mawson Lakes Boulevard, Mawson Lakes, SA 5095, Australia

Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, 381 Royal Parade, Parkville, VIC 3052, Australia

Grup d’Enginyeria de Materials (GEMAT), Institut Quimic de Sarria, Universitat Ramon Llull, Via Augusta 390, Barcelona 08022, Spain

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Centre for Advanced Imaging (CAI), The University of Queensland, Building 57, Research Road, St Lucia, QLD 4072, Australia

Funding

European Regional Development Fund · National Health and Medical Research Council · Australian Research Council · Eesti Teadusagentuur · Government of South Australia

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