DataVXACS Applied Materials & InterfacesPaper
journal article·2016-11-30

Latent Oxidative Polymerization of Catecholamines as Potential Cross-linkers for Biocompatible and Multifunctional Biopolymer Scaffolds

Chetna Dhand, Veluchamy Amutha Barathi, Seow Theng Ong, Mayandi Venkatesh, Sriram Harini, Neeraj Dwivedi, Eunice Tze Leng Goh, Muruganantham Nandhakumar, Jayarama Reddy Venugopal, Silvia Marrero Diaz, Mobashar Hussain Urf Turabe Fazil, Xian Jun Loh, Liu Shou Ping, Roger W. Beuerman, Navin Kumar Verma, Seeram Ramakrishna, Rajamani Lakshminarayanan

ACS Applied Materials & Interfaces· Volume 8· Issue 47
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Source abstract

Abstract

Electrospinning of naturally occurring biopolymers for biological applications requires postspinning cross-linking for endurance in protease-rich microenvironments and prevention of rapid dissolution. The most commonly used cross-linkers often generate cytotoxic byproducts, which necessitate high concentrations or time-consuming procedures. Herein, we report the addition of “safe” catecholamine cross-linkers to collagen or gelatin dope solutions followed by electrospinning yielded junction-containing nanofibrous mats. Subsequent in situ oxidative polymerization of the catecholamines increased the density of soldered junctions and maintained the porous nanofiber architecture. This protocol imparted photoluminescence to the biopolymers, a smooth noncytotoxic coating, and good mechanical/structural stability in aqueous solutions. The utility of our approach was demonstrated by the preparation of durable antimicrobial wound dressings and mineralized osteoconductive scaffolds via peptide antibiotics and calcium chloride (CaCl 2 ) incorporation into the dope solutions. The mineralized composite mats consist of amorphous calcium carbonate that enhanced the osteoblasts cell proliferation, differentiation, and expression of important osteogenic marker proteins. In proof-of-concept experiments, antibiotic-loaded mats displayed superior antimicrobial properties relative to silver (Ag)-based dressings, and accelerated wound healing in a porcine deep dermal burn injury model.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterialsComposites

OpenAlex topics: Polymer Surface Interaction Studies · Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore 169856, Singapore

Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore

Lee Kong Chian School of Medicine, Nanyang Technological University, Experimental Medicine Building, 59 Nanyang Drive, Singapore 636921, Singapore

Department of Electrical and Computer Engineering, National University of Singapore, 3 Engineering Drive 3, Singapore 117583, Singapore

Center for Nanofibers and Nanotechnology and Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore

Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A *STAR), Singapore 117602, Singapore

Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou 510632, China

Funding

National Medical Research Council · Ministry of Education - Singapore · Singapore National Eye Centre · Lee Kong Chian School of Medicine, Nanyang Technological University

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