DataVXACS Applied Materials & InterfacesPaper
journal article·2016-10-26

Prominent Vascularization Capacity of Mesenchymal Stem Cells in Collagen–Gold Nanocomposites

Shu-Chen Hsieh, Hui-Jye Chen, Shan-hui Hsu, Yi-Chin Yang, Cheng-Ming Tang, Mei-Yun Chu, Pei-Ying Lin, Ru-Huei Fu, Mei-Lang Kung, Yun-Wen Chen, Bi-Wen Yeh, Huey-Shan Hung

ACS Applied Materials & Interfaces· Volume 8· Issue 42
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Source abstract

Abstract

The ideal characteristics of surface modification on the vascular graft for clinical application would be with excellent hemocompatibility, endothelialization capacity, and antirestenosis ability. Here, Fourier transform infrared spectroscopy (FTIR), surface enhanced Raman spectroscopy (SERS), atomic force microscopy (AFM), contact angle (θ) measurement, and thermogravimetric analysis (TGA) were used to evaluate the chemical and mechanical properties of collagen-gold nanocomposites (collagen+Au) with 17.4, 43.5, and 174 ppm of Au and suggested that the collagen+Au with 43.5 ppm of Au had better biomechanical properties and thermal stability than pure collagen. Besides, stromal-derived factor-1α (SDF-1α) at 50 ng/mL promoted the migration of mesenchymal stem cells (MSCs) on collagen+Au material through the α5β3 integrin/endothelial oxide synthase (eNOS)/metalloproteinase (MMP) signaling pathway which can be abolished by the knockdown of vascular endothelial growth factor (VEGF). The potentiality of collagen+Au with MSCs for vascular regeneration was evaluated by our in vivo rat model system. Artery tissues isolated from an implanted collagen+Au-coated catheter with MSCs expressed substantial CD-31 and α-SMA, displayed higher antifibrotic ability, antithrombotic activity, as well as anti-inflammatory response than all other materials. Our results indicated that the implantation of collagen+Au-coated catheters with MSCs could be a promising strategy for vascular regeneration.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · Tissue Engineering and Regenerative Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C.

Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.

School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, R.O.C.

Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, R.O.C.

Rehabilitation Engineering Research Center, National Taiwan University, Taipei, Taiwan, R.O.C.

Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.

Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan, R.O.C.

Graduate Institute of Immunology, China Medical University, Taichung, Taiwan, R.O.C.

Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan, R.O.C.

Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.

Translational Medicine Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Funding

China Medical University Hospital · Kaohsiung Medical University · Ministry of Science and Technology, Taiwan

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