DataVXACS Applied Materials & InterfacesPaper
journal article·2021-05-12Open access

Carbon Nanotubes/Regenerated Silk Composite as a Three-Dimensional Printable Bio-Adhesive Ink with Self-Powering Properties

Silvia Bittolo Bon, Irene Chiesa, Micaela Degli Esposti, Davide Morselli, Paola Fabbri, Carmelo De Maria, Antonino Morabito, Riccardo Coletta, Martino Calamai, Francesco Saverio Pavone, Rodolfo Tonin, Amelia Morrone, Giacomo Giorgi, Luca Valentini

ACS Applied Materials & Interfaces· Volume 13· Issue 18
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Source abstract

Abstract

In this study, regenerated silk (RS) obtained from Bombyx Mori cocoons is compounded with carboxyl-functionalized carbon nanotubes (f-CNTs) in an aqueous environment for the fabrication of functional bio-adhesives. Molecular interactions between RS and carboxyl groups of CNTs result in structural increase of the β-sheet formation, obtaining a resistant adhesive suitable for a wet biological substrate. Moreover, the functionalization of CNTs promotes their dispersion in RS, thus enabling the production of films with controlled electrical conductivity. The practical utility of such a property is demonstrated through the fabrication of a piezoelectric device implanted in a rat to monitor the breathing in vivo and to be used as a self-powered system. Finally, RS/f-CNTs were used as a printable biomaterial ink to three dimensionally print bilayer hollow tubular structures composed of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and RS. Initial tests carried out by seeding and growing human skin fibroblasts demonstrated that the 3D printed bilayer hollow cylindrical structures offer a suitable surface for the seeded cells to attach and proliferate. In general, the herein proposed RS/f-CNT composite serves as a versatile material for solvent-free dispersion processing and 3D printing, thus paving a new approach to prepare multifunctional materials with potential applications of great interest in sealing biological substrates and implantable devices for regenerative medicine.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

NanomaterialsBiomaterialsCompositesMaterials processing

OpenAlex topics: Silk-based biomaterials and applications · Electrospun Nanofibers in Biomedical Applications · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Dipartimento di Ingegneria Civile e Ambientale, Università degli Studi di Perugia, Strada di Pentima 4, Terni 05100, Italy

Italian Consortium for Science and Technology of Materials (INSTM), Via Giusti 9, Firenze 50121, Italy

Department of Ingegneria dell’Informazione and Research Center E. Piaggio, University of Pisa, Largo Lucio Lazzarino 1, Pisa 56122, Italy

Department of Civil Chemical, Environmental and Materials Engineering (DICAM), Università; di Bologna, Via Terracini 28, Bologna 40131, Italy

Department of Pediatric Surgery, Meyer Children’s Hospital, Viale Pieraccini 24, Firenze 50139, Italy

Dipartimento Neuroscienze, Psicologia, Area del Farmaco e della Salute del Bambino NEUROFARBA, Università degli Studi di Firenze, Viale Pieraccini 6, Firenze 50121, Italy

School of Health and Society, University of Salford, Salford M5 4WT, United Kingdom

European Laboratory for Non-linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino (FI) 50129, Italy

National Institute of Optics -National Research Council (CNR-INO), Sesto Fiorentino (FI) 50129, Italy

Department of Physics, University of Florence, Sesto Fiorentino (FI) 50121, Italy

Molecular and Cell Biology Laboratory, Paediatric Neurology Unit and Laboratories, Neuroscience Department, Meyer Children’s Hospital, Firenze 50139, Italy

Dipartimento di Ingegneria Civile e Ambientale (DICA), Università degli Studi di Perugia, Via G. Duranti 93, Perugia 06125, Italy

CNR-SCITEC, Perugia I-06123, Italy

Funding

Ministero dell?Istruzione, dell?Universit? e della Ricerca · H2020 European Research Council

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