DataVXACS Applied Materials & InterfacesPaper
journal article·2020-02-05

Electrosprayed Soft Capsules of Millimeter Size for Specifically Delivering Fish Oil/Nutrients to the Stomach and Intestines

Panpan Wang, Min Li, Daixu Wei, Mengzhen Ding, Lina Tao, Xunwei Liu, Fengping Zhang, Ningping Tao, Xichang Wang, Mingyuan Gao, Jian Zhong

ACS Applied Materials & Interfaces· Volume 12· Issue 5
Publisher page
Source abstract

Abstract

Contrasting to the traditional centimeter-sized soft capsules that are difficult to swallow or micro/nanometer-sized soft capsules that suffer from limited loading capacity for fish oil/nutrients and lowered stability, the millimeter-sized soft capsules with good enough stability could be a potential solution in solving these problems. Herein, we report millimeter-sized soft core-shell capsules of 0.42-1.85 mm with an inner diameter of 0.36-1.75 mm, for fish oil/nutrients, obtained through an electrospray approach upon optimization of different fabrication parameters such as applied voltage, sodium alginate concentration, shell/core feeding rate ratio, times of feeding rate, and types of coaxial needles. Further in vitro and in vivo studies reveal that the resulting soft capsules were apparently weakened and became mechanically destructive in the simulated small intestine solution and were totally destroyed in the simulated small intestine solution if they were first treated in the simulated stomach solution but not in the simulated stomach solution, which makes the millimeter-sized capsules useful as containers for specific delivery of fish oils and lipophilic nutrients to the stomach and intestines with excellent in vivo bioavailability (>90%). The whole fabrication approach is very facile with no complicated polymer modification and formulations involved, which endows the resulting soft capsules with broad application prospect in food and drug industries.
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Research context

PolymersNanomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Solar-Powered Water Purification Methods · Electrohydrodynamics and Fluid Dynamics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National R&D Branch Center for Freshwater Aquatic Products Processing Technology (Shanghai), Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs of the People’s Republic of China, Shanghai Engineering Research Center of Aquatic-Product Processing and Preservation, College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, China

Department of Medical Image, 960 Hospital of PLA (Jinan Military General Hospital), No. 25, Shifan Road, Jinan City, Shandong Province 250031, People’s Republic of China

College of Life Sciences and Medicine, Northwest University, Xi’an, Shaanxi 710069, People’s Republic of China,

School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China

Sichuan Willtest Technology Co., Ltd., Chengdu, Sichuan Province, China,Key Laboratory of Nutritional and Healty Cultivation of Aquatic-Product and Livestock-Poultry, Ministry of Agriculture and Rural Affairs of the People’s Republic of China, Tongwei Co., Ltd., Chengdu, Sichuan Province 610041, China

CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Funding

Ministry of Science and Technology of the People's Republic of China · Shanghai Municipal Education Commission

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