Effect of a Controlled Release of Epinephrine Hydrochloride from PLGA Microchamber Array: In Vivo Studies

Olga A. Sindeeva; Olga I. Gusliakova; Olga A. Inozemtseva; Arkady S. Abdurashitov; Ekaterina P. Brodovskaya; Meiyu Gai; Valery V. Tuchin; Dmitry A. Gorin; Gleb B. Sukhorukov

doi:10.1021/acsami.8b15109

journal article·2018-11-07

Effect of a Controlled Release of Epinephrine Hydrochloride from PLGA Microchamber Array: In Vivo Studies

Olga A. Sindeeva, Olga I. Gusliakova, Olga A. Inozemtseva, Arkady S. Abdurashitov, Ekaterina P. Brodovskaya, Meiyu Gai, Valery V. Tuchin, Dmitry A. Gorin, Gleb B. Sukhorukov

ACS Applied Materials & Interfaces· Volume 10· Issue 44

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Source abstract

Abstract

This paper presents the synthesis of highly biocompatible and biodegradable poly(lactide- co-glycolide) (PLGA) microchamber arrays sensitive to low-intensity therapeutic ultrasound (1 MHz, 1-2 W, 1 min). A reliable method was elaborated that allowed the microchambers to be uniformly filled with epinephrine hydrochloride (EH), with the possibility of varying the cargo amount. The maximum load of EH was 4.5 μg per array of 5 mm × 5 mm (about 24 pg of EH per single microchamber). A gradual, spontaneous drug release was observed to start on the first day, which is especially important in the treatment of acute patients. Ultrasound triggered a sudden substantial release of EH from the films. In vivo real-time studies using a laser speckle contrast imaging system demonstrated changes in the hemodynamic parameters as a consequence of EH release under ultrasound exposure. We recorded a decrease in blood flow as a vascular response to EH release from a PLGA microchamber array implanted subcutaneously in a mouse. This response was immediate and delayed (1 and 2 days after the implantation of the array). The PLGA microchamber array is a new, promising drug depot implantable system that is sensitive to external stimuli.

Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Polymer Surface Interaction Studies · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Engineering and Materials Science, Queen Mary University of London, Mile End, Eng, 215, London E1 4NS, United Kingdom

Ogarev Mordovia State University, 68 Bolshevistskaya Street, Saransk 430005, Russia

Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russia

Max Plank Institute of Polymer Research, 10 Ackermannweg, Mainz 55128, Germany

Interdisciplinary Laboratory of Biophotonics, Tomsk State University, 36 Lenin Avenue, Tomsk 634050, Russia

Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control of RAS, 24 Rabochaya Street, 410028 Saratov, Russia

Laboratory of Biophotonics, Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, Nobel Street, Building 3, Moscow 121205, Russia

Funding

Ministry of Education and Science of the Russian Federation · Russian Academy of Sciences · Government of the Russian Federation · Russian Presidential Scholarship

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