DataVXACS Applied Materials & InterfacesPaper
journal article·2018-09-19

Fabrication of Multifoliate PtRu Bimetallic Nanocomplexes for Computed Tomography Imaging and Enhanced Synergistic Thermoradiotherapy

Yaoyao Deng, Xin Tian, Shuanglong Lu, Mingxing Xie, Hai Hu, Rui Zhang, Feng Lv, Liang Cheng, Hongwei Gu, Youliang Zhao, Yue Pan

ACS Applied Materials & Interfaces· Volume 10· Issue 37
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Source abstract

Abstract

To improve the efficiency of cancer therapy, we developed multifoliate PEGylated PtRu bimetallic nanocomplexes (PtRu-PEG BNCs) as multifunctional theranostic nanoagents for computed tomography (CT) imaging and synergistic thermoradiotherapy. The synthesized PtRu-PEG BNCs with uniform size and morphology exhibit excellent stability, notable photothermal effect, and good biocompatibility. As compared with other platinum nanomaterials, the PtRu-PEG BNCs are able to absorb near-infrared laser energy and present excellent photothermal conversion efficiency (44.5%). Multifoliate PtRu-PEG BNCs can be applied to CT imaging and radiotherapy (RT) because of the presence of platinum. Unlike a single therapy method, the integration of photothermal therapy with RT can effectively induce cell apoptosis and generate an obvious synergistic effect. Hence, the as-prepared nanocomplexes can be used as multifunctional theranostic nanoagents.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Gold and Silver Nanoparticles Synthesis and Applications · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P. R. China

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P. R. China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University · Priority Academic Program Development of Jiangsu Higher Education Institutions · Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University · Suzhou City · Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University

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