Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles
Source abstract
Abstract
Weak intensity and poor penetration depth are two big obstacles toward clinical use of Cerenkov luminescence imaging (CLI). In this proof-of-concept study, we overcame these limitations by using lanthanides-based radioluminescent microparticles (RLMPs), called terbium doped Gd2O2S. The characterization experiment showed that the emission excited by Cerenkov luminescence can be neglected whereas the spectrum experiment demonstrated that the RLMPs can actually be excited by γ-rays. A series of in vitro experiments demonstrated that RLMPs significantly improve the intensity and the penetration capacity of CLI, which has been extended to as deep as 15 mm. In vivo pseudotumor study further prove the huge potential of this enhancement strategy for Cerenkov luminescence imaging in living animal studies.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Luminescence Properties of Advanced Materials · Atomic and Subatomic Physics Research · Optical Imaging and Spectroscopy Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education & School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, China
Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
Funding
Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Shaanxi Province
References (45)
Show source-provided references
1. Li C. Q. · J. Nucl. Med. · 2011 · 52 · 126810.2967/jnumed.110.082859 ↗
2. Pandey S. K. · Mol. Imaging · 2014 · 13 · 110.2310/7290.2014.00005 ↗
3. Zhang Y. · Mol. Pharmaceutics · 2012 · 9 · 64510.1021/mp200592m ↗
4. Nahrendorf M. · Proc. Natl. Acad. Sci. U. S. A. · 2010 · 107 · 791010.1073/pnas.0915163107 ↗
5. Robertson R. · Phys. Med. Biol. · 2009 · 54 · N35510.1088/0031-9155/54/16/N01 ↗
6. Xu Y. · J. Nucl. Med. · 2012 · 53 · 31210.2967/jnumed.111.094623 ↗
7. Liu H. G. · PLoS One · 2010 · 5 · e947010.1371/journal.pone.0009470 ↗
8. Robertson R. · J. Nucl. Med. · 2011 · 52 · 176410.2967/jnumed.111.091710 ↗
9. Ruggiero A. · J. Nucl. Med. · 2010 · 51 · 112310.2967/jnumed.110.076521 ↗
10. Thorek D. L. J. · Small · 2014 · 10 · 372910.1002/smll.201400733 ↗
11. Jeong S. Y. · Endocr. J. · 2011 · 58 · 57510.1507/endocrj.K11E-051 ↗
12. Spinelli A. E. · J. Biomed. Opt. · 2013 · 18 · 02050210.1117/1.JBO.18.2.020502 ↗
13. Balkin E. R. · Cancer Res. · 2014 · 74 · 584610.1158/0008-5472.CAN-14-0764 ↗
14. Madru R. · Am. J. Nucl. Med. Mol. Imaging · 2014 · 4 · 60
15. 10.2967/jnumed.113.12726610.2967/jnumed.113.127266 ↗
16. Liu H. · J. Nucl. Med. · 2012 · 53 · 157910.2967/jnumed.111.098541 ↗
17. Cao X. · Biomed. Opt. Express · 2014 · 5 · 366010.1364/BOE.5.003660 ↗
18. Xu Y. · J. Nucl. Med. · 2011 · 52 · 200910.2967/jnumed.111.092965 ↗
19. Lewis M. A. · Opt. Lett. · 2010 · 35 · 388910.1364/OL.35.003889 ↗
20. Bernhard Y. · Chem. Commun. (Camb.) · 2014 · 50 · 671110.1039/C4CC01690D ↗
21. Dothager R. S. · PLoS One · 2010 · 5 · e1330010.1371/journal.pone.0013300 ↗
22. Kotagiri N. · Angew. Chem., Int. Ed. · 2013 · 52 · 775610.1002/anie.201302564 ↗
23. Thorek D. L. · Nat. Med. · 2013 · 19 · 134510.1038/nm.3323 ↗
24. Ma X. · PLoS One · 2013 · 8 · e7792610.1371/journal.pone.0077926 ↗
25. Smith A. M. · Nat. Nanotechnol. · 2009 · 4 · 71010.1038/nnano.2009.326 ↗
26. Sun C. · Adv. Mater. · 2011 · 23 · H19510.1002/adma.201100919 ↗
27. Liu X. · IEEE Trans. Biomed. Eng. · 2014 · 61 · 162110.1109/TBME.2013.2294633 ↗
28. Sudheendra L. · Chem. Mater. · 2014 · 26 · 188110.1021/cm404044n ↗
29. Chen H. · Analyst · 2011 · 136 · 343810.1039/c0an00931h ↗
30. Shen J. · Dalton Trans. · 2008 · 568710.1039/b805306e ↗
31. Kumar V. · Chem. Eng. J. · 2014 · 255 · 54110.1016/j.cej.2014.06.027 ↗
32. Som S. · J. Appl. Phys. · 2014 · 115 · 19310110.1063/1.4876316 ↗
33. Kumar V. · Appl. Phys. A: Mater. Sci. Process. · 2014 · 116 · 178510.1007/s00339-014-8331-5 ↗
34. Som S. · Dalton Trans. · 2014 · 43 · 986010.1039/C4DT00349G ↗
35. Carpenter C. · Med. Phys. · 2010 · 37 · 401110.1118/1.3457332 ↗
36. Carpenter C. M. · Opt. Express · 2012 · 20 · 1159810.1364/OE.20.011598 ↗
37. Chen H. · ACS Nano · 2013 · 7 · 117810.1021/nn304369m ↗
38. Chen D. · Med. Phys. · 2013 · 40 · 03111110.1118/1.4790694 ↗
39. Chen D. · Appl. Phys. Lett. · 2014 · 105 · 19110410.1063/1.4901436 ↗
40. Sun C. · Adv. Mater. · 2011 · 23 · H19510.1002/adma.201100919 ↗
41. Tian Y. · J. Alloys Compd. · 2007 · 433 · 31310.1016/j.jallcom.2006.06.075 ↗
42. Liu H. G. · Small · 2010 · 6 · 108710.1002/smll.200902408 ↗
43. Xu L. · Cryst. Growth Des. · 2009 · 9 · 312910.1021/cg801068k ↗
44. Chatterjee D. K. · Biomaterials · 2008 · 29 · 93710.1016/j.biomaterials.2007.10.051 ↗
45. Xiong L. · Biomaterials · 2010 · 31 · 707810.1016/j.biomaterials.2010.05.065 ↗