Application of Graphdiyne in Surface-Assisted Laser Desorption Ionization Mass Spectrometry

Peiqi Luo; Liping Wang; Lixia Jiang; Jie Sun; Yafeng Li; Huihui Liu; Caiqiao Xiong; Zongxiu Nie

doi:10.1021/acsami.0c18280

journal article·2021-01-13

Application of Graphdiyne in Surface-Assisted Laser Desorption Ionization Mass Spectrometry

Peiqi Luo, Liping Wang, Lixia Jiang, Jie Sun, Yafeng Li, Huihui Liu, Caiqiao Xiong, Zongxiu Nie

ACS Applied Materials & Interfaces· Volume 13· Issue 1

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Source abstract

Abstract

Graphdiyne (GD) is a new kind of carbon nanomaterial which has carbon-carbon triple bonds to form a layered structure. Here, we report the application of GD as the matrix for small molecule analysis in laser desorption ionization mass spectrometry (LDI MS). The GD matrix displayed two advantages: little background in the low mass range and good molecular ion signal in negative ion mode for many small molecules, e.g., fatty acids, amino acids, peptides, and drugs can be obtained in negative ion mode. By comparing the signal intensity of tetraphenylborate and juglone with and without GD existing, it was found that GD can enhance both of the desorption efficiency and ionization efficiency in LDI. Through analysis of the serum samples from liver cancer patients and healthy people, the GD-assisted LDI MS results showed that fatty acids could be used as potential biomarkers for the early diagnosis of liver cancer.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Mass Spectrometry Techniques and Applications · Analytical Chemistry and Chromatography · Ion-surface interactions and analysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

University of Chinese Academy of Sciences, Beijing 100049, China

Centre of Reproductive Medicine, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, China

Gannan Medical University, Ganzhou 341000, China

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States

National Centre for Mass Spectrometry in Beijing, Beijing, 100190, China

Funding

National Natural Science Foundation of China

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