DataVXACS Applied Materials & InterfacesPaper
journal article·2021-10-27

In Vivo Evaluation of Multifunctional Gold Nanorods for Boron Neutron Capture and Photothermal Therapies

Krishna R. Pulagam, Malou Henriksen-Lacey, Kepa B. Uribe, Carlos Renero-Lecuna, Jatish Kumar, Alexandra Charalampopoulou, Angelica Facoetti, Nicoletta Protti, Vanessa Gómez-Vallejo, Zuriñe Baz, Vished Kumar, Ana Sánchez-Iglesias, Saverio Altieri, Unai Cossío, Desire Di Silvio, Angel M. Martínez-Villacorta, Ane Ruiz de Angulo, Luka Rejc, Luis M. Liz-Marzán, Jordi Llop

ACS Applied Materials & Interfaces· Volume 13· Issue 42
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Source abstract

Abstract

Cu-labeled multifunctionalized AuNRs proved to be radiochemically stable and capable of being accumulated in the tumor after intravenous administration in a mouse xenograft model of gastrointestinal cancer. The resulting multifunctional AuNRs showed high biocompatibility and the capacity to induce local heating under external stimulation and trigger cell death in heterogeneous cancer spheroids as well as the capacity to decrease cell viability under neutron irradiation in cancer cells. These results position our nanoconjugates as suitable candidates for combined BNCT/PTT therapies.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Boron Compounds in Chemistry · Nanoparticle-Based Drug Delivery · Boron and Carbon Nanomaterials Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, Donostia-San Sebastian 20014, Spain

Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Paseo de Miramón 194, Donostia-San Sebastian 20014, Spain

Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati 517507, India

Research and Development Department, CNAO National Center for Oncological Hadrontherapy, Pavia 27100, Italy

Department of Physics, University of Pavia, Pavia 27100, Italy

National Institute of Nuclear Physics, Pavia Section, Pavia 27100, Italy

CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Science & Technology Park bld 801 A, Derio 48160, Bizkaia, Spain

Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, Ljubljana SI-1000, Slovenia

Ikerbasque, Basque Foundation for Science, Bilbao 48013, Spain

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid 28029, Spain

Funding

Ministerio de Econom??a y Competitividad · Spanish State Research Agency

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