journal article·2022-06-08

Star-Peptide Polymers are Multi-Drug-Resistant Gram-Positive Bacteria Killers

Wenyi Li, Sara Hadjigol, Alicia Rasines Mazo, James Holden, Jason Lenzo, Steven J. Shirbin, Anders Barlow, Sadegh Shabani, Tao Huang, Eric C. Reynolds, Greg G. Qiao, Neil M. O’Brien-Simpson

ACS Applied Materials & Interfaces· Volume 14· Issue 22
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Abstract

Antibiotic resistance in bacteria, especially Gram-positive bacteria like Staphylococcus aureus, is gaining considerable momentum worldwide and unless checked will pose a global health crisis. With few new antibiotics coming on the market, there is a need for novel antimicrobial materials that target and kill multi-drug-resistant (MDR) Gram-positive pathogens like methicillin-resistant Staphylococcus aureus (MRSA). In this study, using a novel mixed-bacteria antimicrobial assay, we show that the star-peptide polymers preferentially target and kill Gram-positive pathogens including MRSA. A major effect on the activity of the star-peptide polymer was structure, with an eight-armed structure inducing the greatest bactericidal activity. The different star-peptide polymer structures were found to induce different mechanisms of bacterial death both in vitro and in vivo. These results highlight the potential utility of peptide/polymers to fabricate materials for therapeutic development against MDR Gram-positive bacterial infections.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Antimicrobial Peptides and Activities · Bacteriophages and microbial interactions · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

ACTV Research Group, Melbourne Dental School, Centre for Oral Health Research, Royal Dental Hospital and The Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, Parkville, Victoria 3010, Australia

Polymer Science Group, Department of Chemical & Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia

Melbourne Dental School, Centre for Oral Health Research, Royal Dental Hospital and The Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, Parkville, Victoria 3010, Australia

Materials Characterisation and Fabrication Platform, Melbourne School of Engineering, University of Melbourne, Parkville, Victoria 3010, Australia

Department of Biomedical Engineering, Melbourne School of Engineering, University of Melbourne, Parkville, Victoria 3010, Australia

Funding

Australian Dental Research Foundation · National Health and Medical Research Council · Australian Research Council · Cancer Council Victoria

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