journal article·2020-07-15

Mesoporous Bi-Containing Radiosensitizer Loading with DOX to Repolarize Tumor-Associated Macrophages and Elicit Immunogenic Tumor Cell Death to Inhibit Tumor Progression

Xiaojia Qin, Jie Liu, Yunhua Xu, Bing Li, Jingyi Cheng, Xiaodong Wu, Jianping Zhang, Zhengwang Liu, Renli Ning, Yuhao Li, Yingjian Zhang, Yun Sun, Jiade J. Lu

ACS Applied Materials & Interfaces· Volume 12· Issue 28
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Abstract

Tumor-associated macrophages (TAMs) were a major component of tumor, which comprised up to 50% of tumor mass, and correlated with poor prognosis in more than 80% of cases. TAMs were resistant to radiotherapy and chemotherapy, and radiation could further activate TAMs to promote tumor progression. Herein, we explored a kind of Bi-based mesoporous upconversion nanophosphor (UCNP) loaded with doxorubicin (UCNP-DOX) to elicit immunogenic tumor cell death and repolarize TAMs to an antitumor M1-like type for strengthening the tumor-specific antitumor immune effects of X-ray radiotherapy. The repolarization effect of UCNP-DOX with X-ray was confirmed in THP-1 cell line, in vivo mouse model, and hydrothorax of a non-small-cell lung carcinoma patient. Moreover, the UCNP-DOX and X-ray radiation could elicit immunogenic tumor necrosis, presenting more tumor antigens for tumor-specific immune response. In a cell co-incubation system, activated macrophages could significantly inhibit cancer colony formation, migration, and invasion. After treatment, xenografted tumor in mice was also found to be significantly regressed and presented substantial CD8-positive T cells. This study opens the door to further enhance the abscopal effects and inhibit the metastasis in radiotherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Immune cells in cancer · Nanoplatforms for cancer theranostics · Phagocytosis and Immune Regulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center, Shanghai 201321, China

Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201321, China

Shanghai Engineering Research Center for Molecular Imaging Probes, Shanghai 200032, China

Institute of Bismuth Science & College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China

Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China

Department of Research and Development, Shanghai Proton and Heavy Ion Center, Shanghai 201321, China

Department of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Shanghai 201321, China

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai 201321, China

Funding

Natural Science Foundation of Shanghai · Ministry of Science and Technology of the People's Republic of China · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Shanghai Rising-Star Program · Science and Technology Development Fund of Shanghai Pudong New Area

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