DataVXACS Applied Materials & InterfacesPaper
journal article·2021-11-24

Biomimetic Joint Paint for Efficient Cartilage Repair by Simultaneously Regulating Cartilage Degeneration and Regeneration in Pigs

Wei Wei, Yuanzhu Ma, Xianzhu Zhang, Wenyan Zhou, Hongwei Wu, Jingwei Zhang, Junxin Lin, Chenqi Tang, Youguo Liao, Chenglin Li, Xiaozhao Wang, Xudong Yao, Yi Wen Koh, Wenwen Huang, Hongwei Ouyang

ACS Applied Materials & Interfaces· Volume 13· Issue 46
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Source abstract

Abstract

Irregular partial-thickness cartilage defect is a common pathogenesis of osteoarthritis (OA) with no available treatment in clinical practice. Currently, cartilage tissue engineering is only suitable for a limited area of full-thickness cartilage defect. Here, we design a biomimetic joint paint for the intractable partial-thickness cartilage defect repair. The joint paint, composed of a bridging layer of chondroitin sulfate and a surface layer of gelatin methacrylate with hyaluronic acid, can quickly and tightly adhere to the cartilage defect by light activation. Being treated by the joint paint, the group of rabbit and pig models with partial-thickness cartilage defects showed a restoration of a smooth cartilage surface and the preservation of normal glycosaminoglycan content, whereas the untreated control group exhibited serious progressive OA development. This paint treatment functions by prohibiting chondrocyte apoptosis, maintaining chondrocyte phenotype, and preserving the content of glycosaminoglycan in the partial-thickness cartilage defects. These findings illustrated that the biomimetic joint paint is an effective and revolutionary therapeutics for the patients with noncurable partial-thickness cartilage defects.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Silk-based biomaterials and applications · Periodontal Regeneration and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China

Zhejiang University−University of Edinburgh Institute, Zhejiang University, Hangzhou 310000, Zhejiang, China

Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China

International Institutes of Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, Zhejiang, China

Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China

China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou 310000, Zhejiang, China

Funding

Ministry of Science and Technology of the People's Republic of China · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province

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