journal article·2020-01-15

Microfluidic Printing of Three-Dimensional Graphene Electroactive Microfibrous Scaffolds

Huaibin Qing, Yuan Ji, Wenfang Li, Guoxu Zhao, Qingzhen Yang, Xiaohui Zhang, Zhengtang Luo, Tian Jian Lu, Guorui Jin, Feng Xu

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Abstract

Graphene materials have attracted special attention because of their electrical conductivity, mechanical properties, and favorable biocompatibility. Although various methods have been developed for fabricating micro/nano conductive fibrous scaffolds, it is still challenging to fabricate the three-dimensional (3D) graphene fibrous scaffolds. Herein, we developed a new method, termed as microfluidic 3D printing technology (M3DP), to fabricate 3D graphene oxide (GO) microfibrous scaffolds with an adjustable fiber length, fiber diameter, and scaffold structure by integrating the microfluidic spinning technology with a programmable 3D printing system. GO microfibrous scaffolds were then transformed into conductive reduced graphene oxide (rGO) microfibrous scaffolds by hydrothermal reduction. Our results demonstrated that the fabricated 3D fibrous graphene scaffolds exhibited tunable structures, maneuverable mechanical properties, and good electrical conductivity and biocompatibility, as reflected by the adhesion and proliferation of SH-SY5Y cells on the graphene microfibrous scaffolds in an obviously oriented manner. The developed M3DP would be a powerful tool for fabricating 3D graphene microfibrous scaffolds for electroactive tissue regeneration and drug-screening applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Graphene and Nanomaterials Applications · 3D Printing in Biomedical Research · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Key Laboratory for Technology and Application of Metal Toughening, Guangdong Institute of Materials and Processing, Guangzhou 510650, P.R.China

School of Material Science and Chemical Engineering, Xi’an Technological University, Xi’an 710021, P.R. China

Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon 999077, Hong Kong

State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P. R. China

Nanjing Center for Multifunctional Lightweight Materials and Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 21006, P. R. China

Funding

National Natural Science Foundation of China · Joint Fund of China Ministry of Education for Equipment Pre-research · Fundamental Research Funds for the Central Universities · Natural Science Basic Research Plan in Shaanxi Province of China · China Postdoctoral Science Foundation funded project · Research Grant Council of Hong Kong SAR · NSFC-RGC Joint Research Scheme · Key Research and Development Program of Shaanxi · GDAS' Project of Science and Technology Development

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