Cross-Linked Pillar[6]arene Nanosponges Fabricated by the Use of a Supra-Amphiphilic Template: Cargo Encapsulation and Overcoming Multidrug Resistance
Source abstract
Abstract
We report a general fabrication method for water-soluble pillar[n]arene nanosponges (NS) by the use of a supra-amphiphilic template. For the first time, a supra-amphiphilic template is used to conveniently control the size of host molecule-based NS. The intrinsic cavity of water-soluble pillar[6]arene could stably encapsulate dyes (acridine orange and indocyanine green) and antitumor drugs (doxorubicin hydrochloride and mitoxantrone) by host–guest interaction. NS could deliver antitumor drugs to cancer cells. Multidrug resistance (MDR) of cancer cells (MCF-7/ADR) is overcome by the use of NS with a ninefold reduction in the IC50 value compared to that of the free drug (3.4 μM vs 34.4 μM). Mechanistic studies show that stable encapsulation of the antitumor drug is the reason to overcome MDR.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Supramolecular Chemistry and Complexes · Supramolecular Self-Assembly in Materials · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
Department of Neurosurgery, Huashan Hospital of Fudan University, 12 Middle Wulumuqi Road, Shanghai 200032, China
Funding
National Natural Science Foundation of China
References (43)
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