pH-Triggered Peptide Self-Assembly for Targeting Imaging and Therapy toward Angiogenesis with Enhanced Signals

Yixia Qian; Weizhi Wang; Zihua Wang; Xiangqian Jia; Qiuju Han; Iman Rostami; Yuehua Wang; Zhiyuan Hu

doi:10.1021/acsami.8b00583

journal article·2018-03-07Open access

pH-Triggered Peptide Self-Assembly for Targeting Imaging and Therapy toward Angiogenesis with Enhanced Signals

Yixia Qian, Weizhi Wang, Zihua Wang, Xiangqian Jia, Qiuju Han, Iman Rostami, Yuehua Wang, Zhiyuan Hu

ACS Applied Materials & Interfaces· Volume 10· Issue 9

Publisher page Open full text

Source abstract

Abstract

Mild acidic environment and angiogenesis are two typical characteristics of tumor. The specific response toward both lower pH and angiogenesis may enhance the targeting ability both for drug and diagnostic probe delivery. Herein, we present a kind of dual responding self-assembled nanotransformation material that is tumor angiogenesis targeting and pH triggered based on amphiphilic conjugation between peptides (STP) and aromatic molecules (tetraphenylethylene (TPE)). The morphology of the self-assembled peptide conjugates is responsibly changed from nanoparticles in neutral condition to nanofibers in acidic condition, which "turn on" the in vivo targeting imaging and accelerate the efficient drug delivery and in vivo therapy. On the basis of the well-controlled nanotransformation both in vitro and in vivo, we envisioned the successful demonstration of the responding materials would open a new avenue in turn on targeting imaging diagnostics and specific cancer therapeutics.

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Research context

Nanomaterials

OpenAlex topics: Cultural Industries and Urban Development · History, Culture, and Society · Historical and Modern Theater Studies

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Affiliations

CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, P. R. China

University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Centre for Neuroscience Research, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, Fujian, P. R. China

Funding

Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China · Chinese Academy of Sciences · Beijing Talents Fund · Beijing Municipality

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