DataVXACS Applied Materials & InterfacesPaper
journal article·2016-04-13

Fabrication of Mesoporous Silica Nanoparticle with Well-Defined Multicompartment Structure as Efficient Drug Carrier for Cancer Therapy in Vitro and in Vivo

Anhe Wang, Yang Yang, Yanfei Qi, Wen Qi, Jinbo Fei, Hongchao Ma, Jie Zhao, Wei Cui, Junbai Li

ACS Applied Materials & Interfaces· Volume 8· Issue 14
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Source abstract

Abstract

Vaterite particles are composed of particulate CaCO3 nanoparticles, which offer an ideal platform to synthesize architectures with hierarchical structure. Herein we show that mesoporous silica particles with well-defined multicompartment structure are fabricated by employing vaterite particles as templates. The obtained silica particles inherited the structure feature of vaterite and had excellent biocompatibility and biodegradability. Moreover, the silica particles were established as an efficient anticancer drugs carrier compared with hollow silica particles, which could be applied in cancer therapy in vitro and in vivo. The silica particles obtained here offer a cheap, facile, environmentally friendly avenue to assembly of hierarchical drugs carriers.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Calcium Carbonate Crystallization and Inhibition · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China

School of Public Health, Jilin University, Changchun 130021, China

Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · National Key Foundation for Exploring Scientific Instrument · Norman Bethune Health Science Center, Jilin University

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