Gd3+-1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-2-hydroxypropyl-β-cyclodextrin/Pluronic Polyrotaxane as a Long Circulating High Relaxivity MRI Contrast Agent
Source abstract
Abstract
A multivalent magnetic resonance imaging agent based on a 2-hydroxypropyl-β-cyclodextrin (HPCD):Pluronic F127 polyrotaxane carrier has been synthesized, and its blood pool contrast properties have been characterized. This Gd3+-DO3A-HPCD/Pluronic polyrotaxane construct is shown to circulate for more than 30 min and provide >100-fold vascular enhancement relative to the monomeric Gd3+-DO3A-HPCD control that is rapidly cleared via the kidney. The high r1 relaxivity at 37 °C (23.83 mM(-1) s(-1) at 1.5 T; 34.08 mM(-1) s(-1) at 0.5 T), extended blood circulation, well-known pharmacology of the polyrotaxane precursors, and absence of acute toxicity make it a highly attractive blood pool contrast agent candidate.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Lanthanide and Transition Metal Complexes · Advanced MRI Techniques and Applications · MRI in cancer diagnosis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States
Department of Chemistry, Multi-disciplinary Cancer Research Facility, Purdue University, 1203 W. State Street, West Lafayette, Indiana 47907, United States
Funding
Ara Parseghian Medical Research Foundation · Indiana Clinical and Translational Sciences Institute · National Cancer Institute · National Institute of General Medical Sciences · National Institute of Biomedical Imaging and Bioengineering
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