journal article·2022-07-20

Electreted Sandwich Membranes with Persistent Electrical Stimulation for Enhanced Bone Regeneration

Zhiguang Qiao, Meifei Lian, Xingzhou Liu, Xing Zhang, Yu Han, Bing Ni, Ruida Xu, Bin Yu, Qingrong Xu, Kerong Dai

ACS Applied Materials & Interfaces· Volume 14· Issue 28
Publisher page

Abstract

Physiologically relevant electrical microenvironments play an indispensable role in manipulating bone metabolism. Although implanted biomaterials that simulate the electrical properties of natural tissues using conductive or piezoelectric materials have been introduced in the field of bone regeneration, the application of electret materials to provide stable and persistent electrical stimulation has rarely been studied in biomaterial design. In this study, a silicon dioxide electret-incorporated poly(dimethylsiloxane) (SiO2/PDMS) composite electroactive membrane was designed and fabricated to explore its bone regeneration efficacy. SiO2 electrets were homogeneously dispersed in the PDMS matrix, and sandwich-like composite membranes were fabricated using a facile layer-by-layer blade-coating method. Following the encapsulation, electret polarization was conducted to obtain the electreted composite membranes. The surface potential of the composite membrane could be adjusted to a bone-promotive biopotential by tuning the electret concentration, and the prepared membranes exhibited favorable electrical stability during an observation period of up to 42 days. In vitro biological experiments indicated that the electreted SiO2/PDMS membrane promoted cellular activity and osteogenic differentiation of mesenchymal stem cells. In vivo, the electreted composite membrane remarkably facilitated bone regeneration through persistent endogenous electrical stimulation. These findings suggest that the electreted sandwich-like membranes, which maintain a stable and physiological electrical microenvironment, are promising candidates for enhancing bone regeneration.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Planarian Biology and Electrostimulation · Bone Tissue Engineering Materials · Neuroscience and Neural Engineering

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedic Surgery, Renji Hospital, South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai 201112, China

Clinical and Translational Research Center for 3D Printing Technology, Medical 3D Printing Innovation Research Center, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China

Department of Prosthodontics, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Department of Rehabilitation, Huadong Hospital, Fudan University, Shanghai 200040, China

State Key Laboratory of Mechanical Systems and Vibration, Shanghai Jiao Tong University, Shanghai 200240, China

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

School of Life Science, East China Normal University, Shanghai 200241, China

State Key Laboratory for Modification of Chemical Fibers & Polymer Materials, College of Materials Science & Engineering, Donghua University, Shanghai 201620, China

Funding

Ministry of Education of the People's Republic of China · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Shanghai Municipal Commission of Health and Family Planning Foundation · Medical-Engineering Cross Fund of Shanghai Jiao Tong University

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