Nanodiamonds Inhibit Cancer Cell Migration by Strengthening Cell Adhesion: Implications for Cancer Treatment
Source abstract
Abstract
Nanodiamonds (NDs) are a type of biocompatible nanomaterial with easily modified surfaces and are considered as promising candidates in biomedicine. In this work, the inhibition of tumor cell migration by carboxylated nanodiamonds (cNDs) was investigated. AFM-based single cell adhesion and F-actin staining experiments demonstrated that cNDs treatment could enhance cell adhesion and impair assembly of the cytoskeleton. The mechanism analysis of the regulatory protein expression level also proved that cNDs could inhibit the migration of Hela cells by preventing the epithelial-mesenchymal transition (EMT) process through the transforming growth factor β (TGF-β) signaling pathway. The in vivo pulmonary metastasis model also showed that cNDs effectively reduced the metastasis of murine B16 melanoma cells. In summary, cNDs have been demonstrated to inhibit cancer cell migration in vitro and decrease tumor metastasis in vivo. Therefore, cNDs might have potential utility for specific cancer treatment.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Diamond and Carbon-based Materials Research · Carbon Nanotubes in Composites · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
University of Chinese Academy of Sciences, Beijing 100190, P. R. China
Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China
Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Yokohama, 223-8522, Japan
Funding
Bureau of International Cooperation, Chinese Academy of Sciences · National Natural Science Foundation of China · Southeast University
References (54)
Show source-provided references
1. 10.1038/s41563-019-0566-210.1038/s41563-019-0566-2 ↗
2. 10.1016/j.biomaterials.2016.06.01710.1016/j.biomaterials.2016.06.017 ↗
3. 10.1021/nl400972r10.1021/nl400972r ↗
4. 10.1073/pnas.121454711010.1073/pnas.1214547110 ↗
5. 10.1016/j.biomaterials.2013.11.02010.1016/j.biomaterials.2013.11.020 ↗
6. 10.1021/nl403254910.1021/nl4032549 ↗
7. 10.1016/j.jcis.2017.11.00910.1016/j.jcis.2017.11.009 ↗
8. 10.1002/smll.20190223810.1002/smll.201902238 ↗
9. 10.1002/adfm.20110267010.1002/adfm.201102670 ↗
10. 10.1016/j.cossms.2016.05.00810.1016/j.cossms.2016.05.008 ↗
11. 10.1016/j.carbon.2015.11.06110.1016/j.carbon.2015.11.061 ↗
12. 10.1039/C9NR07037K10.1039/C9NR07037K ↗
13. 10.1088/0957-4484/21/31/31510610.1088/0957-4484/21/31/315106 ↗
14. 10.1016/j.jcis.2018.11.02810.1016/j.jcis.2018.11.028 ↗
15. 10.1002/jbio.20170001110.1002/jbio.201700011 ↗
16. 10.1002/adfm.20160120710.1002/adfm.201601207 ↗
17. 10.1016/j.actbio.2019.01.02510.1016/j.actbio.2019.01.025 ↗
18. 10.1021/acsnano.7b0174410.1021/acsnano.7b01744 ↗
19. 10.1016/j.jpha.2019.09.00310.1016/j.jpha.2019.09.003 ↗
20. 10.1039/C7TB00449D10.1039/C7TB00449D ↗
21. 10.1002/smll.20090230510.1002/smll.200902305 ↗
22. 10.1002/pssa.20160009410.1002/pssa.201600094 ↗
23. 10.2147/IJN.S10485910.2147/IJN.S104859 ↗
24. 10.1021/acsanm.8b0205610.1021/acsanm.8b02056 ↗
25. 10.1242/jcs.09559610.1242/jcs.095596 ↗
26. 10.1016/j.diamond.2020.10780910.1016/j.diamond.2020.107809 ↗
27. 10.1016/j.carbon.2020.11.03110.1016/j.carbon.2020.11.031 ↗
28. 10.1021/acsami.6b0831110.1021/acsami.6b08311 ↗
29. 10.1021/nn100748k10.1021/nn100748k ↗
30. 10.1021/acsbiomaterials.8b0142810.1021/acsbiomaterials.8b01428 ↗
31. 10.1016/j.semcdb.2017.06.02910.1016/j.semcdb.2017.06.029 ↗
32. 10.1016/j.tcb.2011.04.00810.1016/j.tcb.2011.04.008 ↗
33. 10.1016/j.ceb.2016.06.00210.1016/j.ceb.2016.06.002 ↗
34. 10.1007/s13277-014-2163-y10.1007/s13277-014-2163-y ↗
35. 10.1002/anie.20130988510.1002/anie.201309885 ↗
36. 10.1038/nrc.2017.11810.1038/nrc.2017.118 ↗
37. 10.1016/j.cell.2019.10.02910.1016/j.cell.2019.10.029 ↗
38. 10.1016/j.cellsig.2016.07.01610.1016/j.cellsig.2016.07.016 ↗
39. 10.1007/s00109-015-1283-110.1007/s00109-015-1283-1 ↗
40. 10.1016/j.bbi.2015.08.00610.1016/j.bbi.2015.08.006 ↗
41. 10.1038/nrm375810.1038/nrm3758 ↗
42. 10.1039/C9MH00388F10.1039/C9MH00388F ↗
43. 10.1002/smll.20110123310.1002/smll.201101233 ↗
44. 10.3390/cancers1112197610.3390/cancers11121976 ↗
45. 10.1016/j.yexcr.2017.04.00610.1016/j.yexcr.2017.04.006 ↗
46. 10.1093/carcin/bgy17810.1093/carcin/bgy178 ↗
47. 10.1016/j.jsbmb.2020.10572310.1016/j.jsbmb.2020.105723 ↗
48. 10.1021/acsnano.8b0412810.1021/acsnano.8b04128 ↗
49. 10.1002/smll.20160213310.1002/smll.201602133 ↗
50. 10.1186/s11671-017-1982-310.1186/s11671-017-1982-3 ↗
51. 10.1080/14686996.2018.144431810.1080/14686996.2018.1444318 ↗
52. 10.1111/imm.1203710.1111/imm.12037 ↗
53. 10.1038/labinvest.2013.11610.1038/labinvest.2013.116 ↗
54. 10.1016/j.etap.2014.06.00610.1016/j.etap.2014.06.006 ↗