DataVXACS Applied Materials & InterfacesPaper
journal article·2021-05-19

CuWO4 Nanodots for NIR-Induced Photodynamic and Chemodynamic Synergistic Therapy

Yanyan Cui, Xi Chen, Yan Cheng, Xinyi Lu, Jiajia Meng, Ziwei Chen, Mengke Li, Chengcheng Lin, Yaling Wang, Jian Yang

ACS Applied Materials & Interfaces· Volume 13· Issue 19
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Source abstract

Abstract

Dynamic therapy, such as photodynamic therapy (PDT) or chemodynamic therapy (CDT), is one of the most promising therapeutic strategies for tumors. Integrating the advantages of near-infrared-induced PDT and CDT can potentially improve the therapeutic performance. A single primitive nanostructure, CuWO4 nanodots, was developed. It could generate reactive oxygen species under 808 nm light irradiation and release copper ions into the acid tumor microenvironment, thereby boosting Fenton-like reactions. The PDT and CDT would occur when the nanodots were introduced into the tumor tissue and irradiated under 808 nm light. The results of combined PDT and CDT antitumor studies showed the effective inhibition of tumor tissue growth, thereby suggesting that the nanodots are candidate agents for synergistic antitumor applications.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Ga2O3 and related materials · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optoelectronics, Beijing Institute of Technology, Beijing 100081, China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China

University of Chinese Academy of Sciences, Beijing 100049, China

Funding

Ministry of Science and Technology of the People's Republic of China · Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety · National Natural Science Foundation of China · Department of S and T for Social Development · Chinese Academy of Sciences · CAMS Innovation Fund for Medical Sciences

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