Linear Alternating Supramolecular Photosensitizer for Enhanced Photodynamic Therapy
Source abstract
Abstract
Supramolecular polymers with facile and versatile architectures via noncovalent connection present great potential in biological fields. Herein, a linear alternating supramolecular polymer is constructed via host–guest inclusion interaction between cyclodextrin dimer (CD2) and bifunctional adamantane-conjugated porphyrin (TPP-Ad2). The supramolecular alternating structure of CD/TPP could not only suppress the aggregation of PSs to improve the photophysical properties because of the steric hindrance but also enhance the water solubility of PSs induced from cyclodextrin moieties. The nanoplatform obtained by this linear alternating supramolecular polymer (TPP-Ad2/CD2) presents significantly enhanced photodynamic therapy (PDT) efficacy, providing a promising path for PDT.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Porphyrin and Phthalocyanine Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
Funding
Ministry of Education of the People's Republic of China · National Natural Science Foundation of China
References (66)
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