journal article·2020-07-22

Ultrasound and Near-Infrared Light Dual-Triggered Upconversion Zeolite-Based Nanocomposite for Hyperthermia-Enhanced Multimodal Melanoma Therapy via a Precise Apoptotic Mechanism

Lulu Zheng, Yule Zhang, Hui Lin, Shifei Kang, Yuhao Li, Di Sun, Mengya Chen, Zixin Wang, Ziao Jiao, Yuwen Wang, Bo Dai, Songlin Zhuang, Dawei Zhang

ACS Applied Materials & Interfaces· Volume 12· Issue 29
Publisher page

Abstract

High reactive oxygen species (ROS) generation efficiency and induction of targeted cell apoptosis are recognized as key objectives to achieve a highly efficient strategy for cancer therapy with minimum side effects of inflammatory reactions. However, it is still a challenge to realize higher therapeutic efficiency with a cell apoptosis model. Herein, we present strong upconversion luminescent biosafe cores derived from Linde Type A (LTA) zeolites and modification with targeted/therapeutic drugs for multimodal therapy, in which sonodynamic therapy (SDT) combined with photodynamic therapy (PDT) increases therapeutic efficiency especially in deep sites of tumor via producing cytoplasmic ROS and mitochondrial superoxide and photothermal therapy (PTT) enhances PDT effects via higher fluorescence resonance energy transfer (FRET) efficacy attributed to an increased temperature. Furthermore, the transcriptomic analysis reveals that cellular internalization of the nanosystem can lead to tumor ablation via cell apoptosis. We expect that the multimodal therapy based on LTA zeolite drug nanocarriers could be applied in the cancer therapeutics in the near future.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence Properties of Advanced Materials · Photoacoustic and Ultrasonic Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Engineering Research Center of Optical Instrument and System, The Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China

Department of Environmental Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China

College of Science, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China

Shanghai Jiao Tong University Affiliated Sixth People’s Hospital & Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, P. R. China

Shanghai Institute of Intelligent Science and Technology, Tongji University, Shanghai 200092, P. R. China

Funding

Ministry of Science and Technology of the People's Republic of China · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Defense Industrial Technology Development Program

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