DataVXACS Applied Materials & InterfacesPaper
journal article·2018-12-12Open access

Dual Functionalization of Nanoparticles for Generating Corona-Free and Noncytotoxic Silica Nanoparticles

Jessica Fernanda Affonso de Oliveira, Francine Ramos Scheffer, Ryan F. Landis, Érico Teixeira Neto, Vincent M. Rotello, Mateus Borba Cardoso

ACS Applied Materials & Interfaces· Volume 10· Issue 49
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Source abstract

Abstract

Protein coronas form on the surfaces of nanomaterials in biological fluids. This layer of proteins affects the properties of nanomaterials, altering their behavior and masking engineered functionality. The use of nonfouling moieties reduces or prevents corona formation; however, these ligands typically complicate functionalization. We present here a surface modification strategy for silica nanoparticles using specific molar ratios of zwitterionic and amine moieties. Through proper balance of ligands, we were able to generate particles that featured reactive "handles", while retaining nonfouling properties, high hemocompatibility, and low cytotoxicity.
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Research context

Nanomaterials

OpenAlex topics: Autism Spectrum Disorder Research · Behavioral and Psychological Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratório Nacional de Nanotecnologia (LNNano) and Laboratório Nacional de Luz Síncrotron (LNLS)/Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), CEP 13083-970, Caixa Postal, 6192 Campinas, São Paulo, Brazil

Instituto de Química (IQ), Universidade Estadual de Campinas (UNICAMP), CEP 13083-970, Caixa Postal, 6154 Campinas, São Paulo, Brazil

Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States

Funding

National Institute of Biomedical Imaging and Bioengineering · Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico · Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo · National Institute of General Medical Sciences · Laborat?rio Nacional de Nanotecnologia · Laborat?rio Nacional de Luz S?ncrotron

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