DataVXACS Applied Materials & InterfacesPaper
journal article·2016-02-24

Self-Healing Spongy Coating for Drug “Cocktail” Delivery

Xia-chao Chen, Ke-feng Ren, Wen-xi Lei, Jia-hui Zhang, M. Cristina L. Martins, Mário A. Barbosa, Jian Ji

ACS Applied Materials & Interfaces· Volume 8· Issue 7
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Source abstract

Abstract

Optimized ratio in the codelivery of therapeutics is of crucial importance to promote the synergism rather than the antagonistic effects. In this study, a self-healing spongy coating was described to facilitate the surface-mediated delivery of drug "cocktails" proportionally. The formation of spongy structures within the coating was achieved by acidic treatment and freeze-drying. Various drug combinations can be readily integrated through wicking method and subsequent micropore self-healing. The ratio of drug loading can be precisely regulated by the composition of loading solution and the embedded drugs were released in proportion according to the initial ratio of drug combination.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced Drug Delivery Systems · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

i3S−Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto 4200-135, Portugal

INEB−Instituto de Engenharia Biomédica, Universidade do Porto, Rua do Campo Alegre, 823, Porto 4150-180, Portugal

ICBAS−Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto 4050-313, Portugal

Funding

Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province · Department of Science and Technology of Zhejiang Province · Zhejiang Province

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