journal article·2021-06-23

Preparation and Characterization of Oleanolic Acid-Based Low-Molecular-Weight Supramolecular Hydrogels Induced by Heating

Jie-Ping Fan, Hui Zhong, Xue-Hong Zhang, Tian-Tao Yuan, Hui-Ping Chen, Hai-Long Peng

ACS Applied Materials & Interfaces· Volume 13· Issue 24
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Abstract

The natural-product-based low-molecular-weight supramolecular hydrogels (LMWSHs) induced by heating are rarely reported. In this work, a simple salt of oleanolic acid (OA) and choline ([choline][OA]) was used as the natural product hydrogelator (NPHG) to form LMWSHs. Unlike common sol-gel transitions, the OA-based LMWSH displayed a unique property with which the system could undergo a phase transition from the sol state to the gel state upon heating. Moreover, the phase separation was observed in sol and gel states when the temperature was elevated with nonreversible transparent-turbid transitions. LMWSHs showed good stability and injectability and the potential to be a drug delivery vehicle for sustained release of drugs. In this regard, this work provided a facile approach to designing an OA-based NPHG for preparing heat-induced LMWSHs.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Supramolecular Self-Assembly in Materials · Polydiacetylene-based materials and applications · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Poyang Lake Ecology and Bio-Resource Utilization of Ministry of Education, Nanchang University, Nanchang 330031, China

School of Resource, Environmental and Chemical Engineering, Nanchang University, Nanchang 330031, China

School of Foreign Language, Nanchang University, Nanchang 330031, China

Funding

Ministry of Science and Technology of the People's Republic of China · Jiangxi Provincial Department of Science and Technology · Major Discipline Academic and Technical Leaders Training Program of Jiangxi Province · National Natural Science Foundation of China · Jiangxi Province Young Scientists · Special Funds for Graduate Student Innovation in Jiangxi Province

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