journal article·2015-10-21

Multilayered Magnetic Gelatin Membrane Scaffolds

Sangram K. Samal, Vitaly Goranov, Mamoni Dash, Alessandro Russo, Tatiana Shelyakova, Patrizio Graziosi, Lisa Lungaro, Alberto Riminucci, Marc Uhlarz, Manuel Bañobre-López, Jose Rivas, Thomas Herrmannsdörfer, Jayakumar Rajadas, Stefaan De Smedt, Kevin Braeckmans, David L. Kaplan, V. Alek Dediu

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Abstract

A versatile approach for the design and fabrication of multilayer magnetic scaffolds with tunable magnetic gradients is described. Multilayer magnetic gelatin membrane scaffolds with intrinsic magnetic gradients were designed to encapsulate magnetized bioagents under an externally applied magnetic field for use in magnetic-field-assisted tissue engineering. The temperature of the individual membranes increased up to 43.7 °C under an applied oscillating magnetic field for 70 s by magnetic hyperthermia, enabling the possibility of inducing a thermal gradient inside the final 3D multilayer magnetic scaffolds. On the basis of finite element method simulations, magnetic gelatin membranes with different concentrations of magnetic nanoparticles were assembled into 3D multilayered scaffolds. A magnetic-gradient-controlled distribution of magnetically labeled stem cells was demonstrated in vitro. This magnetic biomaterial-magnetic cell strategy can be expanded to a number of different magnetic biomaterials for various tissue engineering applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Micro and Nano Robotics · Tissue Engineering and Regenerative Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Spintronic Devices Division, Institute for Nanostructured Materials ISMN-CNR, Via Gobetti 101, 40129 Bologna, Italy

Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, United States

Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium

Polymer Chemistry & Biomaterials Research Group, Ghent University, Krijgslaan 281, S4-Bis, B-9000 Ghent, Belgium

Laboratory of Biomechanics and Technology Innovation, NABI, Rizzoli Orthopaedic Institute, Via di Barbiano 1/10, 40136 Bologna, Italy

Osteoarticular Research Group, Centre for Genomic and Experimental Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom

Dresden High Magnetic Field Laboratory (HLD-EMFL), Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany

International Iberian Nanotechnology Laboratory (INL), Av. Mestre José Veiga, 4715-330 Braga, Portugal

Department of Applied Physics, Faculty of Physics, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain

Biomaterials and Advanced Drug Delivery Laboratory, Cardiovascular Pharmacology Division, Stanford Cardiovascular Institute, Stanford University, 1050 Arastradero, Palo Alto, California 94304, United States

Funding

Seventh Framework Programme · National Institute of Biomedical Imaging and Bioengineering · Air Force Office of Scientific Research

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