Label-Free Luminescent Switch-On Probe for Ochratoxin A Detection Using a G-Quadruplex-Selective Iridium(III) Complex
Source abstract
Abstract
A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R2=0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · DNA and Nucleic Acid Chemistry · Bacteriophages and microbial interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, China
Funding
Agence Nationale de la Recherche · Universidade de Macau · Health and Medical Research Fund · Research Grants Council, University Grants Committee, Hong Kong · Hong Kong Baptist University · Science and Technology Development Fund of Macao Special Administrative Region · Shum Yiu Foon Sum Bik Chuen Memorial Centre for Cancer and Inflammation Research, Hong Kong Baptist University · State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University
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