DataVXACS Applied Materials & InterfacesPaper
journal article·2019-01-30

Transdermal Delivery of 5-Aminolevulinic Acid by Nanoethosome Gels for Photodynamic Therapy of Hypertrophic Scars

Zheng Zhang, Ying Liu, Yunsheng Chen, Lexiang Li, Ping Lan, Dannong He, Jie Song, Yixin Zhang

ACS Applied Materials & Interfaces· Volume 11· Issue 4
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Source abstract

Abstract

5-Aminolevulinic acid (ALA)-loaded nanoethosome (ALA-ES) gels are successfully prepared to realize a transdermal delivery of ALA, and they provide a feasible approach for the photodynamic therapy (PDT) of hypertrophic scars (HS). Herein, the morphological and physicochemical features indicate that ALA-ES is stable in gel matrix. In vitro transdermal penetration studies suggest ALA-ES gels can overcome the compact dermal barrier and deliver more ALA into human HS tissue. In vivo delivery studies further reveal that ALA-ES gels can penetrate into rabbit HS tissue to facilitate ALA accumulating in hypertrophic scar fibroblast (HSF) and converting into protoporphyrin IX in the cytoplasm. Utilizing transmission electron microscopy, the visual in vivo penetration process indicates ALA-ES penetrate into HS tissue utilizing its deformable membrane, enters HSF by a pinocytotic-like mechanism, and then releases ALA in the cytoplasm. Subsequently, PDT efficacy is assessed using rabbit HS models. The morphological and histological analysis reveal that ALA-ES gels can improve HS by promoting HSF apoptosis, remodelling collagen fibers and increasing MMP3 expression. The results demonstrate that ALA-ES gels are suitable in clinical treatment of HS and make a substantial progress within the field.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Dermatologic Treatments and Research · Laser Applications in Dentistry and Medicine · Ocular Surface and Contact Lens

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, P.R. China

Cosmetic Laser Center, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Roadd, Shanghai 200011, P.R. China

Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Instrument for Diagnosis and Therapy, 800 Dongchuan Rd, Shanghai Jiao Tong University, Shanghai 200240, P.R. China

Department of Orthopedic, Changzheng Hospital, Second Military Medical University, Shanghai 200240, China

Institute for Advanced and Applied Chemical Synthesis, Jinan University, Zhuhai, 519070, China

Shanghai National Engineering Research Center for Nanotechnology, 245 Jiachuan Road, Shanghai 200237, PR China

Funding

China Postdoctoral Science Foundation · Shanghai Municipal Education Commission · National Natural Science Foundation of China · Shanghai Ninth People's Hospital, Shanghai Jiao Tong University

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